IMidazo [1,2-B] pyrazin-3 - carboxylic acid ethyl ester

Base Information

• Chemical Name: IMidazo [1,2-B] pyrazin-3 - carboxylic acid ethyl ester
• CAS No.: 1286754-14-0
• Molecular Formula: C9H9N3O2
• Molecular Weight: 191.18666
• Mol file: 1286754-14-0.mol

Synonyms:IMidazo [1,2-B] pyrazin-3 - carboxylic acid ethyl ester;Imidazo[1,2-a]pyrazine-3-carboxylic acid ethyl ester;Ethyl imidazo[1,2-a]pyrazine-3-carboxylate;Midazo [1,2-B] pyrazin-3 - carboxylic acid ethyl ester

Chemical Property of IMidazo [1,2-B] pyrazin-3 - carboxylic acid ethyl ester

Chemical Property:

• PKA: 1.50±0.30(Predicted)
• PSA: 56.49000
• Density: 1.33±0.1 g/cm3(Predicted)
• LogP: 0.90600
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

Ethylimidazo[1,2-a]pyrazine-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of IMidazo [1,2-B] pyrazin-3 - carboxylic acid ethyl ester

There total 2 articles about IMidazo [1,2-B] pyrazin-3 - carboxylic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.9%

2-Aminopyrazine (5049-61-6) + ethyl Bromopyruvate (70-23-5) → imidazo[1,2-a]pyrazine-3-carboxylic acid ethyl ester (1286754-14-0)

Guidance literature:

In methanol; 1,2-dimethoxyethane; at 0 - 30 ℃; for 4.5h; Inert atmosphere;

Reference yield: 28.9%

2-Aminopyrazine (5049-61-6) + ethanol (64-17-5) + bromopyruvic acid (1113-59-3) → imidazo[1,2-a]pyrazine-3-carboxylic acid ethyl ester (1286754-14-0)

Guidance literature:

2-Aminopyrazine; bromopyruvic acid; In methanol; 1,2-dimethoxyethane; at 20 - 30 ℃; for 4h;

ethanol; for 4h; Reflux;

Reference yield:

imidazo[1,2-a]pyrazine-3-carboxylic acid ethyl ester (1286754-14-0) + benzyl chloroformate (501-53-1,94274-21-2) → 5,6-dihydro-8H-imidazo[1,2-a]pyrazine-3,7-dicarboxylic acid 7-benzyl-3-ethyl ester

Guidance literature:

imidazo[1,2-a]pyrazine-3-carboxylic acid ethyl ester; With hydrogenchloride; palladium 10% on activated carbon; hydrogen; In ethanol; ethyl acetate; at 20 ℃;

benzyl chloroformate; With triethylamine; In tetrahydrofuran; ethanol; ethyl acetate; at 20 ℃;

upstream raw materials:

2-Aminopyrazine

ethyl Bromopyruvate

ethanol

bromopyruvic acid

Refernces

• 1、 -. "PHTHALAZINONE KETONE DERIVATIVE, PREPARATION METHOD THEREOF, AND PHARMACEUTICAL USE THEREOF". Paragraph 0176; 0177. . Retrieved 2013/06/04.