2-(5-(difluoroMethyl)-2-fluorophenyl)-4,4,5,5-tetraMethyl-1,3,2-dioxaborolane

Base Information

Chemical Name:2-(5-(difluoroMethyl)-2-fluorophenyl)-4,4,5,5-tetraMethyl-1,3,2-dioxaborolane
CAS No.:1142228-23-6
Molecular Formula:C13H16BF3O2
Molecular Weight:272.075
Hs Code.:2931900090
Mol file:1142228-23-6.mol

Synonyms:2-(5-(difluoroMethyl)-2-fluorophenyl)-4,4,5,5-tetraMethyl-1,3,2-dioxaborolane

Suppliers and Price of 2-(5-(difluoroMethyl)-2-fluorophenyl)-4,4,5,5-tetraMethyl-1,3,2-dioxaborolane

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Matrix Scientific
2-(5-(Difluoromethyl)-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 95%
500mg
$ 444.00

Matrix Scientific
2-(5-(Difluoromethyl)-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 95%
1g
$ 666.00

American Custom Chemicals Corporation
2-(5-(DIFLUOROMETHYL)-2-FLUOROPHENYL)-4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLANE 95.00%
5MG
$ 497.71

A1 Biochem Labs
2-(5-(Difluoromethyl)-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 95%
2.5 g
$ 1250.00

Total 5 raw suppliers

Chemical Property of 2-(5-(difluoroMethyl)-2-fluorophenyl)-4,4,5,5-tetraMethyl-1,3,2-dioxaborolane

Chemical Property:

PSA：18.46000
LogP:3.06250

Purity/Quality:

99% ^*data from raw suppliers

2-(5-(Difluoromethyl)-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane 95% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 2-(5-(difluoroMethyl)-2-fluorophenyl)-4,4,5,5-tetraMethyl-1,3,2-dioxaborolane

There total 1 articles about 2-(5-(difluoroMethyl)-2-fluorophenyl)-4,4,5,5-tetraMethyl-1,3,2-dioxaborolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 886509-99-5
1-bromo-5-difluoromethyl-2-fluorobenzene

: 73183-34-3
bis(pinacol)diborane

: 1142228-23-6
2-(5-(difluoromethyl)-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Guidance literature:: With potassium acetate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; at 90 ℃; for 18h; Inert atmosphere;

Reference yield:

: 1142228-23-6
2-(5-(difluoromethyl)-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 1354288-75-7
5,7-difluoro-N-(5-iodo-2-morpholinopyridin-4-yl)-3-methyl-2-(pyridin-2-yl)quinolin-4-amine

: 1354286-87-5
N-(5-(5-(difluoromethyl)-2-fluorophenyl)-2-morpholinopyridin-4-yl)-5,7-difluoro-3-methyl-2-(pyridin-2-yl)quinolin-4-amine

Guidance literature:: With potassium phosphate; tricyclohexylphosphine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; In 1,4-dioxane; water; at 90 ℃; for 19h; Inert atmosphere;

Reference yield:

: 1142228-23-6
2-(5-(difluoromethyl)-2-fluorophenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

: 1142228-30-5
4-(chloromethyl)-5'-(difluoromethyl)-2-(5,5-dimethyl-1-cyclopenten-1-yl)-2'-fluoro-1,1'-biphenyl

Guidance literature:: Multi-step reaction with 3 steps

1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 19 h / 23 - 90 °C / Inert atmosphere

2: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C

3: thionyl chloride / dichloromethane; N,N-dimethyl-formamide / 0 - 20 °C

With lithium aluminium tetrahydride; thionyl chloride; potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;