RONGALITE

Base Information

• Chemical Name: RONGALITE
• CAS No.: 149-44-0
• Molecular Formula: CH3NaO3S
• Molecular Weight: 118.089
• Hs Code.: 2831.10
• Mol file: 149-44-0.mol

Synonyms:C.I. Reducing Agent 2;Cosmolit;Formaldehyde sodium sulfoxylate;Formaldehydesulfoxylic acid sodium salt;Formapon;Formopan;Hydrolit;Hydroxymethanesulfinic acid sodium salt;Leptacid;Leptacit;NSC 4847;NSC 78331;Redol C;Rodite;Rongalit;Rongalit C;Rongalite;Rongalite C;Sodium (hydroxymethyl)sulfinate;Sodiumhydroxymethanesulfinate;Sodium methanalsulfoxylate;Sodium sulfoxylateformaldehyde;Superlite C;Methanesulfinicacid, hydroxy-, monosodium salt (8CI,9CI);Sodium formaldehydesulfoxylate(7CI);Aldanil;Bleachit D;Bruggolit C;

Chemical Property of RONGALITE

Chemical Property:

• Appearance/Colour: solid
• Vapor Pressure: 0.003Pa at 20℃
• Melting Point: ~120 °C (dec.)
• Boiling Point: 446.4 °C at 760 mmHg
• Flash Point: 223.8 °C
• PSA: 79.57000
• Density: 1.744[at 20℃]
• LogP: -0.31900
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: H2O: 50 mg/mL, clear, colorless
• Water Solubility.: soluble H2O, alcohol [HAW93]

Purity/Quality:

99% ^*data from raw suppliers

Sodium hydroxymethanesulfinate hydrate ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-68-31
• Safety Statements: 26-36-36/37

MSDS Files:

Total 1 MSDS from other Authors

Useful:

• Uses: Pharmaceutic aid (preservative). Sodium Hydroxymethanesulfinate Hydrate is the hydrated version of Sodium Hydroxymethanesulfinate (S634950), which is an organic reductant that is stable in alkaline enviroments but readily decomposes in acidic medium to produce a number of products, one of them being sulfur dioxide. Sodium hydroxymethanesulfinate is also used in conjunction with substituted anilines (e.g. p-Anisidine [A673505]) to synthesize anilinomethanesulfonates.

Technology Process of RONGALITE

There total 5 articles about RONGALITE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) → rongalite (149-44-0)

Guidance literature:

With sodium Oleate; sodium hydrogensulfite; zinc; In water; at 94 ℃; for 4h; further added surfactants; influence od electrodeposited zinc on synthesis;

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + Sodium; 2,2,2-trifluoro-1-hydroxy-ethanesulfinate → 2,2,2-trifluoro-1,1-ethanediol (421-53-4) + rongalite (149-44-0)

Guidance literature:

In water-d2; Yields of byproduct given. Title compound not separated from byproducts;

DOI:10.1016/S0040-4020(01)86325-0

Reference yield:

formaldehyd (50-00-0,30525-89-4,61233-19-0) + sodium hydrogensulfite → rongalite (149-44-0)

Guidance literature:

With zinc; In water; Zinc powder and water are put int reactor at room temp., rapid stirring (homogeneous slurry), addn. of NaHSO3 and HCOH (94°C, 4 h).; iodometric titration; Kinetics;

upstream raw materials:

formaldehyd

water

sodium anilinomethanesulfonate

Aminoiminomethanesulfinic acid

Downstream raw materials:

N-sulfomethyl-sulfanilic acid ; methylaniline-p.ω-disulfonate sodium

bis-(4-dimethylamino-benzyl)-sulfone

2-[ethyl(phenyl)amino]acetonitrile

N-phenylglycinonitrile

Refernces

Androgen receptor affinity of 5'-acyl furanosteroids

10.1021/jm00050a019

The research focuses on the synthesis and evaluation of 5'-acyl furanosteroids for their androgen receptor affinity and antiandrogenic activity. The purpose of this study was to develop new methods to prepare 5'-acetyl derivatives and explore the structure-activity relationships (SAR) of these compounds, aiming to understand their potential as therapeutic agents for conditions like benign prostatic hyperplasia (BPH), acne, and hirsutism. The researchers synthesized a series of 5'-acyl furanosteroids using acid anhydrides and acid chlorides, in the presence or absence of Lewis acids, and evaluated their binding affinity to the androgen receptor and their in vivo antiandrogenic and androgenic activities. The conclusions drawn from the study were that most 5'-acyl furanosteroids maintained androgen receptor affinity but displayed diminished antiandrogenic activity compared to 4,5'-methylsulfonyl furanosteroid. The biological studies revealed that these compounds were either androgens or modest antiandrogens. Electrostatic potential maps of the substructures provided insights into the lack of significant antiandrogenic activity observed in 5'-acyl furanosteroids. Chemicals used in the process included acid anhydrides, acid chlorides, Lewis acids, sodium formaldehyde sulfoxylate, palladium on carbon, and various furanosteroid derivatives.