BenzenaMine, 5-broMo-2-(2-broMoethoxy)-

Base Information

• Chemical Name: BenzenaMine, 5-broMo-2-(2-broMoethoxy)-
• CAS No.: 1235451-65-6
• Molecular Formula: C8H9Br2NO
• Molecular Weight: 294.974
• Hs Code.: 2922299090
• Mol file: 1235451-65-6.mol

Synonyms:BenzenaMine, 5-broMo-2-(2-broMoethoxy)-

Chemical Property of BenzenaMine, 5-broMo-2-(2-broMoethoxy)-

Chemical Property:

• PSA: 35.25000
• LogP: 3.38620
• Storage Temp.: 2-8°C

Purity/Quality:

≥99% ^*data from raw suppliers

5-Bromo-2-(2-bromoethoxy)aniline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BenzenaMine, 5-broMo-2-(2-broMoethoxy)-

There total 2 articles about BenzenaMine, 5-broMo-2-(2-broMoethoxy)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

2-amino-4-bromo-phenol (40925-68-6) + ethylene dibromide (106-93-4) → 5-bromo-2-(2-bromoethoxy)benzenamine (1235451-65-6)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 4h;

Reference yield:

4-bromo-1-(2-bromoethoxy)-2-nitrobenzene (1101858-58-5) → 5-bromo-2-(2-bromoethoxy)benzenamine (1235451-65-6)

Guidance literature:

With tin(II) chloride dihdyrate; In tetrahydrofuran; ethanol; at 20 ℃; for 4h;

DOI:10.1016/j.bmc.2010.06.042

Reference yield: 94.0%

5-bromo-2-(2-bromoethoxy)benzenamine (1235451-65-6) → 6-bromo-3, 4-dihydro-2H-benzo[β][1, 4]oxazine (105655-01-4)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 4h;

upstream raw materials:

4-bromo-1-(2-bromoethoxy)-2-nitrobenzene

2-amino-4-bromo-phenol

ethylene dibromide

Downstream raw materials:

tert-butyl 6-bromo-2,3-dihydrobenzo[b][1,4]oxazine-4-carboxylate

6-bromo-3, 4-dihydro-2H-benzo[β][1, 4]oxazine

Refernces

• 1、 -. "TREATMENT OF CANCERS HAVING K-RAS MUTATIONS". Paragraph 0573. . Retrieved 2013/05/08.
• 2、 Huang, Wenhai,Lv, Dan,Yu, Haiping,Sheng, Rong,Kim, Sun Chol,Wu, Peng,Luo, Kedi,Li, Jia,Hu, Yongzhou. "Dual-target-directed 1,3-diphenylurea derivatives: BACE 1 inhibitor and metal chelator against Alzheimer's disease". experimental part. p. 5610 - 5615. Retrieved 2010/09/14.