105655-01-4

Basic information

• Product Name: 6-Bromo-3,4-dihydro-2H-benzo[1,4]oxazine hydrochloride
• Synonyms: 6-bromo-3,4-dihydro-2H-benzo[b][1,4]oxazine;6-BroMo-3,4-dihydro-2H-benzo[b][1,4]oxazine HCl;6-BROMO-3,4-DIHYDRO-2H-BENZO[1,4]OXAZINE HYDROCHLORIDE;2H-1,4-Benzoxazine, 6-bromo-3,4-dihydro-;6-Bromo-3,4-dihydro-2H-benzo[1,4]oxazine;6-Bromo-3,4-dihydro-2H-1,4-benzoxazine
• CAS NO: 105655-01-4
• Molecular Formula: C₈H₈BrNO
• Molecular Weight: 250.52
• Mol File: 105655-01-4.mol
• Article Data: 21

Chemical Properties

• Boiling Point: 296.364 °C at 760 mmHg
• Flash Point: 133.036 °C
• Appearance: /
• Density: 1.534 g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.58
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 3.59±0.20(Predicted)
• CAS DataBase Reference: 6-Bromo-3,4-dihydro-2H-benzo[1,4]oxazine hydrochloride(CAS DataBase Reference)
• NIST Chemistry Reference: 6-Bromo-3,4-dihydro-2H-benzo[1,4]oxazine hydrochloride(105655-01-4)
• EPA Substance Registry System: 6-Bromo-3,4-dihydro-2H-benzo[1,4]oxazine hydrochloride(105655-01-4)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 105655-01-4(Hazardous Substances Data)

Usage

Uses

6-Bromo-3,4-dihydro-2H-1,4-benzoxazine is a reactant used for the synthesis of N-dichloroacetyl-3,4-dihydro-2H-1,4-benzoxazine derivatives.

InChI:InChI=1/C8H8BrNO/c9-6-1-2-8-7(5-6)10-3-4-11-8/h1-2,5,10H,3-4H2

Upstream product

• 24036-52-0 6-bromo-3,4-dihydro-2H-1,4-benzoxazin-3-one 
• 698982-99-9 methyl 2-(4-bromo-2-nitrophenoxy)acetate 
• 40925-68-6 2-amino-4-bromo-phenol 
• 106-93-4 ethylene dibromide 
• 1235451-65-6 5-bromo-2-(2-bromoethoxy)benzenamine 
• 107986-49-2 N-(5-bromo-2-hydroxyphenyl)acetamide 
• 36749-01-6 2-acetamido-4-bromophenyl acetate 
• 7693-52-9 4-bromo-2-nitrophenol 
• 106-41-2 4-bromo-phenol 
• 188947-78-6 1-(6-bromo-2,3-dihydro-4H-benzo[b][1,4]oxazin-4-yl)ethan-1-one 

Downstream Products

• 719310-31-3 tert-butyl 6-bromo-2,3-dihydrobenzo[b][1,4]oxazine-4-carboxylate 
• 1185265-47-7 4-benzenesulfonyl-6-bromo-3,4-dihydro-2H-benzo[1,4]oxazine 
• 1185265-49-9 N-[4-(6-bromo-2,3-dihydro-benzo[1,4]oxazine-4-sulfonyl)-phenyl]-acetamide 
• 1375419-04-7 2-chloro-6-fluoro-N-(4-((4-fluorophenyl)sulfonyl)-3,4-dihydro-2H-benzo[b][1,4]oxazin-6-yl)benzamide 
• 1256256-24-2 4-methyl-6-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine 
• 939759-09-8 6-iodo-3,4-dihydro-2H-benzo[b][1,4]oxazine 

Relevant articles and documents

Design, synthesis, and bioevaluation of substituted phenyl isoxazole analogues as herbicide safeners

Herbicide safeners enhance herbicide detoxification in crops without affecting target weed sensitivity. To enhance crop tolerance to the toxicity-related stress caused by the herbicide acetochlor (ACT), a new class of substituted phenyl isoxazole derivatives was designed by an intermediate derivatization method as herbicide safeners. Microwave-assisted synthesis was used to prepare the phenyl isoxazole analogues, and all of the structures were confirmed via IR, 1H NMR, 13C NMR, and HRMS. Compound I-1 was further characterized by X-ray diffraction analysis. Bioassay results showed that most of the obtained compounds provided varying degrees of safening against ACT-induced injury by increasing the corn growth recovery, glutathione content, and glutathione S-transferase activity. In particular, compound I-20 showed excellent safener activity against ACT toxicity, comparable to that of the commercial safener benoxacor. Gaussian calculations have been performed and the results indicated that the nucleophilic ability of compound I-20 is higher than that of benoxacor, thus the activity is higher than that of benoxacor. These findings demonstrate that phenyl isoxazole derivatives possess great potential for protective management in cornfields.

Receptor-interacting protein kinase 2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling inhibitors based on a 3,5-diphenyl-2-aminopyridine scaffold

Receptor-interacting protein kinase 2 (RIPK2) is a key mediator of nucleotide-binding oligomerization domain (NOD) cell signaling that has been implicated in various chronic inflammatory conditions. A new class of RIPK2 kinase/NOD signaling inhibitors bas

COMPOSITIONS FOR USE IN METHODS OF INHIBITING PROTEIN KINASES

Identified compounds demonstrate protein kinase inhibitory activity and inhibition of dependent cell signaling pathways, such as NOD2 cell signaling. More specifically, the compounds are demonstrated to inhibit receptor interacting kinase 2 (RIPK2) and/or Activin- like kinase 2 (ALK2). Compounds that are either dual RIPK2/ALK2 inhibitors or that preferentially inhibit RIPK2 or ALK2 could provide therapeutic benefit.