6-Chloro-2-fluoro-3-iodopyridine, 95%

Base Information

• Chemical Name: 6-Chloro-2-fluoro-3-iodopyridine, 95%
• CAS No.: 1187732-65-5
• Molecular Formula: C₅H₂ClFIN
• Molecular Weight: 257.433
• Hs Code.: 2933399090
• Mol file: 1187732-65-5.mol

Synonyms:6-Chloro-2-fluoro-3-iodopyridine, 95%;2-fluoro-3-iodo-6 -chloropyridine

Chemical Property of 6-Chloro-2-fluoro-3-iodopyridine, 95%

Chemical Property:

• Boiling Point: 260.3±35.0 °C(Predicted)
• PKA: -4.59±0.10(Predicted)
• PSA: 12.89000
• Density: 2.129±0.06 g/cm3(Predicted)
• LogP: 2.47870
• Sensitive.: Light Sensitive

Purity/Quality:

HPLC≥98% ^*data from raw suppliers

6-Chloro-2-fluoro-3-iodopyridine 95.0% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-Chloro-2-fluoro-3-iodopyridine, 95%

There total 1 articles about 6-Chloro-2-fluoro-3-iodopyridine, 95% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2-chloro-6-fluoropyridine (20885-12-5) → 6-chloro-2-fluoro-3-iodopyridine (1187732-65-5)

Guidance literature:

2-chloro-6-fluoropyridine; With 2,2,6,6-tetramethylpiperidinylmagnesium chloride lithium chloride complex; In tetrahydrofuran; at -40 ℃; for 2h;

With iodine; In tetrahydrofuran; at 25 ℃; for 16h;

DOI:10.1021/acs.orglett.0c01991

Reference yield: 61.0%

6-chloro-2-fluoro-3-iodopyridine (1187732-65-5) + acetamidine hydrochloride (124-42-5) → 5-chloro-2-methylimidazo<4,5-b>pyridine (40851-92-1)

Guidance literature:

6-chloro-2-fluoro-3-iodopyridine; acetamidine hydrochloride; With caesium carbonate; In dimethyl sulfoxide; at 90 ℃; for 18h; Schlenk technique;

With copper(l) iodide; In dimethyl sulfoxide; at 90 ℃; for 10h; regiospecific reaction; Schlenk technique;

DOI:10.1039/d0ob01904f

Reference yield:

6-chloro-2-fluoro-3-iodopyridine (1187732-65-5) → 6-chloro-3-(chloromethyl)-2-fluoropyridine (1227577-88-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: TurboGrignard / tetrahydrofuran / Cooling

1.2: 0.5 h / 0 °C

1.3: 2 h / 0 - 25 °C

2.1: chloroformic acid ethyl ester / chloroform / 16 h / 0 - 25 °C

With TurboGrignard; chloroformic acid ethyl ester; In tetrahydrofuran; chloroform;

DOI:10.1021/acs.orglett.0c01991

upstream raw materials:

2-chloro-6-fluoropyridine

Downstream raw materials:

N-(5-(4-(dimethylamino)piperidin-1-yl)-6-fluoropyridin-2-yl)-9-((1r,4r)-4-methylcyclohexyl)-9H-pyrido[4′,3′:4,5]pyrrolo[2,3-d]pyrimidin-2-amine

6-chloro-3-(chloromethyl)-2-fluoropyridine

5-chloro-2-methylimidazo<4,5-b>pyridine

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