40851-92-1

Usage

Uses

Used in Pharmaceutical Industry:
5-CHLORO-2-METHYL-3H-IMIDAZO[4,5-B]PYRIDINE is used as a building block for the synthesis of various drugs and pharmaceuticals, contributing to the development of new therapeutic agents.
Used in Antiviral and Antimicrobial Applications:
5-CHLORO-2-METHYL-3H-IMIDAZO[4,5-B]PYRIDINE is used as a potential antiviral and antimicrobial agent, with ongoing research exploring its therapeutic applications in combating viral and bacterial infections.
Used in Organic Synthesis:
5-CHLORO-2-METHYL-3H-IMIDAZO[4,5-B]PYRIDINE is used as a reagent in organic synthesis for the preparation of various other chemical compounds, expanding its utility in the chemical industry.
Safety Precautions:
When handling 5-CHLORO-2-METHYL-3H-IMIDAZO[4,5-B]PYRIDINE, safety precautions should be taken due to its potential health and environmental risks.

Upstream product

• 40851-95-4 6-chloropyridine-2,3-diamine 
• 108-24-7 acetic anhydride 
• 4214-75-9 2-amino-3-nitropyridine 
• 78-39-7 Triethyl orthoacetate 
• 27048-04-0 2-amino-6-chloro-3-nitropyridine 
• 64-19-7 acetic acid 
• 139086-97-8 2-acetamido-6-chloro-3-nitropyridine 
• 16013-85-7 2,6-dicholoro-3-nitropyridine 
• 1187732-65-5 6-chloro-2-fluoro-3-iodopyridine 
• 124-42-5 acetamidine hydrochloride 

Downstream Products

• 219762-28-4 5-bromo-2-methyl-1H-imidazo[4,5-b]pyridine 
• 219764-81-5 3-(2-chloro-4-((cyclohexylmethyl)oxy)benzyl)-2-methyl-3H-imidazo[4,5-b]pyridine-5-carboxylic acid 

Relevant academic research and scientific papers

Access to 2-pyridinylamide and imidazopyridine from 2-fluoropyridine and amidine hydrochloride

Under catalyst-free conditions, an efficient method to synthesize 2-pyridinylamides has been developed, and the protocol uses inexpensive and readily available 2-fluoropyridine and amidine derivatives as the starting materials. Simultaneously, the copper-catalysed approach to imidazopyridine derivatives has been established with high chemoselectivity and regiospecificity. The results suggest that the nitrogen-heterocycles containing iodide substituents can also be compatible for the reaction via the cascade Ullmann-type coupling, and the nucleophilic substitution reaction provides the target products in a one-pot manner.

Sulfonamide compounds and medicinal use thereof

A sulfonamide compound of the formula (I):R 1 --SO 2 NHCO--A--R 2 (I)wherein R 1 is alkyl, alkenyl, alkynyl and the like; A is an optionally substituted heteropolycyclic group except benzimidazolyl, indolyl, 4,7-dihydrobenzimidazolyl and 2,3-dihydrobenzoxazinyl; X is alkylene, oxa, oxa(lower)alkylene and the like; and R 2 is optionally substituted aryl, substituted biphenylyl and the like, a salt thereof and a pharmaceutical composition comprising the same. The sulfonamide compound is effective for the diseases treatable based on their blood sugar level-depressing activity, cGMP-PDE (especially PDE-V)-inhibiting activity, smooth muscle relaxing activity, bronchodilating activity, vasodilating activity, smooth muscle cell suppressing activity, and antiallergic activity.

SYNTHESIS OF SOME 1-ALKYL-1,4-DIHYDRO-4-OXO-1,7-NAPHTHYRIDINE-3-CARBOXYLIC ACIDS

Reaction of substituted 2-aminopyridines IIIa, IIIb, IIIe, and IIIf with ethyl ethoxymethylene malonate provided corresponding pyridylaminomethylenemalonates Va-Vd, respectively.Thermal cyclization of Va, Vc, and Vd yielded substituted ethyl 4-hydroxy-1,7-naphthyridine-3-carboxylates VIa, VIc, and VId.Compounds VIc and VId treated with morpholine have 8-morpholino derivatives VIe and VIf.These compounds were ethylated to mixtures of N-ethylated (VIIa, VIIb) and O-ethylated products (VIIIa, VIIIb).Compound VIIIb was also prepared from ethyl 4-chloro-6-fluoro-8-morpholino-1,7-naphthyridine-3-carboxylate VIIIc and sodium ethanolate.Esters VIIa and VIIb were hydrolyzed under acidic conditions to the respective acids VIIc and VIId.