2-Chloro-N,6-dimethylpyrimidin-4-amine

Base Information

• Chemical Name: 2-Chloro-N,6-dimethylpyrimidin-4-amine
• CAS No.: 3569-33-3
• Molecular Formula: C₆H₈ClN₃
• Molecular Weight: 157.603
• Hs Code.: 2933599090
• European Community (EC) Number: 852-000-2
• DSSTox Substance ID: DTXSID40600563
• Wikidata: Q82496706
• Mol file: 3569-33-3.mol

Synonyms:3569-33-3;2-Chloro-N,6-dimethylpyrimidin-4-amine;2-Chloro-N,6-dimethyl-4-pyrimidinamine;(2-Chloro-6-methyl-pyrimidin-4-yl)-methyl-amine;MFCD09864578;SCHEMBL3474098;DTXSID40600563;MIRJBFZIBXQRLC-UHFFFAOYSA-N;AKOS011764346;SB57367;AM100715;AS-63563;SY305638;CS-0072571;C74837;EN300-316388;(2-chloro-6-methyl-pyrimidin-4yl)-methyl-amine;A904278;2-Chloro-N,6-dimethyl-4-pyrimidinamine, AldrichCPR;F8883-0818

Chemical Property of 2-Chloro-N,6-dimethylpyrimidin-4-amine

Chemical Property:

• Vapor Pressure: 0.000899mmHg at 25°C
• Boiling Point: 304°C at 760 mmHg
• Flash Point: 137.7°C
• PSA: 37.81000
• Density: 1.275g/cm³
• LogP: 1.55310
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 157.0406750
• Heavy Atom Count: 10
• Complexity: 109

Purity/Quality:

97% ^*data from raw suppliers

2-chloro-N,6-dimethyl-4-pyrimidinamine ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xn
• Statements: 22

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=CC(=NC(=N1)Cl)NC

Technology Process of 2-Chloro-N,6-dimethylpyrimidin-4-amine

There total 5 articles about 2-Chloro-N,6-dimethylpyrimidin-4-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

2,4-dichloro-6-methylpyrimidine (5424-21-5) + methylamine hydrochloride (593-51-1) → 2-chloro-N,6-dimethyl-pyrimidin-4-amine (3569-33-3)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 5h; regioselective reaction;

DOI:10.1016/j.bmcl.2020.127475

Reference yield: 43.0%

2,4-dichloro-6-methylpyrimidine (5424-21-5) + methylamine (74-89-5) → 4-chloro-N,6-dimethyl-2-pyrimidinamine (5738-15-8) + 2-chloro-N,6-dimethyl-pyrimidin-4-amine (3569-33-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In ethanol; at 50 ℃; for 24h;

DOI:10.1002/anie.202002546

Reference yield: 43.0%

→ 2-chloro-N,6-dimethyl-pyrimidin-4-amine (3569-33-3)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In ethanol; at 50 ℃; for 24h;

upstream raw materials:

2,4-dichloro-6-methylpyrimidine

methylamine

methylamine hydrochloride

2,4-dihydroxy-6-methylpyrimidine