(R)-1-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-3-ethoxy-2,2-difluoro-3-oxopropyl benzoate

Base Information

Chemical Name:(R)-1-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-3-ethoxy-2,2-difluoro-3-oxopropyl benzoate
CAS No.:143234-90-6
Molecular Formula:C17H20F2O6
Molecular Weight:358.339
Hs Code.:
Mol file:143234-90-6.mol

Synonyms:(R)-1-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-3-ethoxy-2,2-difluoro-3-oxopropyl benzoate;2-Deoxy-2,2-difluoro-4,5-O-(1-methylethylidene)-D-erythropentonic acid ethyl ester 3-benzoate

Suppliers and Price of (R)-1-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-3-ethoxy-2,2-difluoro-3-oxopropyl benzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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Total 8 raw suppliers

Chemical Property of (R)-1-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-3-ethoxy-2,2-difluoro-3-oxopropyl benzoate

Chemical Property:

Boiling Point:425.0±45.0 °C(Predicted)
PSA：71.06000
Density:1.231
LogP:2.56190

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (R)-1-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-3-ethoxy-2,2-difluoro-3-oxopropyl benzoate

There total 1 articles about (R)-1-((R)-2,2-dimethyl-1,3-dioxolan-4-yl)-3-ethoxy-2,2-difluoro-3-oxopropyl benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 98-88-4
benzoyl chloride

: 95058-92-7,166376-97-2
(erytro) ethyl-3-(2,2-dimethyl-1,3-dioxolan-4-yl)-2,2-difluoro-3-hydroxy propionate

: 143234-90-6
Benzoic acid (R)-1-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-ethoxycarbonyl-2,2-difluoro-ethyl ester

Guidance literature:: With 2,6-dimethylpyridine; dmap; In dichloromethane; at 33 - 36 ℃; for 3h;
DOI:10.1055/s-1992-26167

Reference yield:

: 143234-90-6
Benzoic acid (R)-1-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-ethoxycarbonyl-2,2-difluoro-ethyl ester

: 143234-91-7
Benzoic acid (1R,2R)-1-(ethoxycarbonyl-difluoro-methyl)-2,3-dihydroxy-propyl ester

Guidance literature:: With water; trifluoroacetic acid; In acetonitrile; at 78 ℃; for 3h;
DOI:10.1055/s-1992-26167

Reference yield:

: 143234-90-6
Benzoic acid (R)-1-((R)-2,2-dimethyl-[1,3]dioxolan-4-yl)-2-ethoxycarbonyl-2,2-difluoro-ethyl ester

: 122111-07-3
Benzoic acid (2R,3R)-4,4-difluoro-2-hydroxymethyl-5-oxo-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 2 steps

1: trifluoroacetic acid, water / acetonitrile / 3 h / 78 °C

2: toluene / azeotropic distillation until 95-100 deg C (pot temperature)

With water; toluene; trifluoroacetic acid; In acetonitrile;
DOI:10.1055/s-1992-26167