Benzoic acid (2R,3R)-4,4-difluoro-2-hydroxymethyl-5-oxo-tetrahydro-furan-3-yl ester

Base Information

Chemical Name:Benzoic acid (2R,3R)-4,4-difluoro-2-hydroxymethyl-5-oxo-tetrahydro-furan-3-yl ester
CAS No.:122111-07-3
Molecular Formula:C₁₂H₁₀F₂O₅
Molecular Weight:272.205
Hs Code.:

Synonyms:Benzoic acid (2R,3R)-4,4-difluoro-2-hydroxymethyl-5-oxo-tetrahydro-furan-3-yl ester

Suppliers and Price of Benzoic acid (2R,3R)-4,4-difluoro-2-hydroxymethyl-5-oxo-tetrahydro-furan-3-yl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 1 raw suppliers

Chemical Property of Benzoic acid (2R,3R)-4,4-difluoro-2-hydroxymethyl-5-oxo-tetrahydro-furan-3-yl ester

Chemical Property:

Purity/Quality:: 95%+ or 98%+ ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of Benzoic acid (2R,3R)-4,4-difluoro-2-hydroxymethyl-5-oxo-tetrahydro-furan-3-yl ester

There total 8 articles about Benzoic acid (2R,3R)-4,4-difluoro-2-hydroxymethyl-5-oxo-tetrahydro-furan-3-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1010839-84-5
ethyl (3RS)-3-(benzoyloxy)-2,2-difluoro-3-(2,2-dimethyldioxolan-4-yl)propionate

: 122111-07-3
Benzoic acid (2R,3R)-4,4-difluoro-2-hydroxymethyl-5-oxo-tetrahydro-furan-3-yl ester

Guidance literature:: With water; trifluoroacetic acid; In acetonitrile; at 80 ℃; for 5 - 6h; Heating / reflux;

Reference yield:

: 98-88-4
benzoyl chloride

: 122111-07-3,122111-08-4
(D-erythro,D-threo)-2-deoxy-2,2-difluoropentofuranos-1-ulose-3-benzoate

Guidance literature:: Multi-step reaction with 2 steps

1: 96 percent / 2,6-lutidine / 4-dimethylaminopyridine / CH₂Cl₂ / 3 h / 33 - 36 °C

2: 1) trifluoroacetic acid, water, 2) toluene / 1) CH₃CN, 78 deg C, 3 h, 2) azeotropic distillation until 95-100 deg C (pot temperature)

With 2,6-dimethylpyridine; water; toluene; trifluoroacetic acid; dmap; In dichloromethane;
DOI:10.1055/s-1992-26167

Reference yield:

: 98-88-4
benzoyl chloride

: 122111-07-3
Benzoic acid (2R,3R)-4,4-difluoro-2-hydroxymethyl-5-oxo-tetrahydro-furan-3-yl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 96 percent / 2,6-lutidine / 4-dimethylaminopyridine / CH₂Cl₂ / 3 h / 33 - 36 °C

2: trifluoroacetic acid, water / acetonitrile / 3 h / 78 °C

3: toluene / azeotropic distillation until 95-100 deg C (pot temperature)

With 2,6-dimethylpyridine; water; toluene; trifluoroacetic acid; dmap; In dichloromethane; acetonitrile;
DOI:10.1055/s-1992-26167