2-Bromo-5-chloro-3-fluoroisonicotinic acid

Base Information

Chemical Name:2-Bromo-5-chloro-3-fluoroisonicotinic acid
CAS No.:514798-01-7
Molecular Formula:C6H2BrClFNO2
Molecular Weight:254.4409832
Hs Code.:2933399990
DSSTox Substance ID:DTXSID50451381
Nikkaji Number:J1.861.136H
Wikidata:Q82271374
Mol file:514798-01-7.mol

Synonyms:2-Bromo-5-chloro-3-fluoroisonicotinic acid;514798-01-7;2-Bromo-5-chloro-3-fluoropyridine-4-carboxylic acid;DTXSID50451381;MFCD20921503;AKOS016011876;DS-2877;2-Bromo-5-chloro-3-fluoroisonicotinicacid;A871273;2-Bromo-5-chloro-3-fluoroisonicotinic acid, AldrichCPR

Suppliers and Price of 2-Bromo-5-chloro-3-fluoroisonicotinic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

SynQuest Laboratories
2-Bromo-5-chloro-3-fluoro-4-pyridinecarboxylic acid
250 mg
$ 114.00

SynChem
2-BROMO-5-CHLORO-3-FLUOROISONICOTINIC ACID 95%
1 g
$ 450.00

Matrix Scientific
2-Bromo-5-chloro-3-fluoroisonicotinicacid >95%
1g
$ 810.00

Crysdot
2-Bromo-5-chloro-3-fluoroisonicotinicacid 97%
1g
$ 228.00

Chemenu
2-bromo-5-chloro-3-fluoroisonicotinicacid 97%
1g
$ 215.00

Apolloscientific
2-Bromo-5-chloro-3-fluoroisonicotinicacid 97%
250mg
$ 103.00

American Custom Chemicals Corporation
2-BROMO-5-CHLORO-3-FLUOROISONICOTINIC ACID 95.00%
5MG
$ 502.69

Alichem
2-Bromo-5-chloro-3-fluoroisonicotinicacid
1g
$ 998.00

AK Scientific
2-Bromo-5-chloro-3-fluoroisonicotinicacid
1g
$ 651.00

Total 17 raw suppliers

Chemical Property of 2-Bromo-5-chloro-3-fluoroisonicotinic acid

Chemical Property:

PSA：50.19000
LogP:2.33480
Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
XLogP3:2.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:1
Exact Mass:252.89415
Heavy Atom Count:12
Complexity:194

Purity/Quality:

97% ^*data from raw suppliers

2-Bromo-5-chloro-3-fluoro-4-pyridinecarboxylic acid ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=C(C(=C(C(=N1)Br)F)C(=O)O)Cl

Technology Process of 2-Bromo-5-chloro-3-fluoroisonicotinic acid

There total 4 articles about 2-Bromo-5-chloro-3-fluoroisonicotinic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 124-38-9,18923-20-1
carbon dioxide

: 514797-97-8
2-bromo-5-chloro-3-fluoro-pyridine

: 514798-01-7
2-bromo-5-chloro-3-fluoro-4-pyridinecarboxylic acid

Guidance literature:: 2-bromo-5-chloro-3-fluoro-pyridine; With n-butyllithium; diisopropylamine; In tetrahydrofuran; hexane; at -75 ℃; for 2h;

carbon dioxide; In tetrahydrofuran; hexane;
DOI:10.1002/1099-0690(200212)2002:24<4174::AID-EJOC4174>3.0.CO;2-6

Reference yield:

: 89402-43-7
5-chloro-2,3-difluoropyridine

: 514798-01-7
2-bromo-5-chloro-3-fluoro-4-pyridinecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: 91 percent / aq. sodium hydroxide / 20 h / 75 °C

2.1: 97 percent / phosphoryl tribromide / dimethylformamide / 2 h / 130 °C

3.1: butyllithium; diisopropylamine / tetrahydrofuran; hexane / 2 h / -75 °C

3.2: 74 percent / tetrahydrofuran; hexane

With sodium hydroxide; n-butyllithium; diisopropylamine; phosphorus(V) oxybromide; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;
DOI:10.1002/1099-0690(200212)2002:24<4174::AID-EJOC4174>3.0.CO;2-6

Reference yield:

: 514797-96-7
5-chloro-3-fluoro-2(1H)-pyridinone

: 514798-01-7
2-bromo-5-chloro-3-fluoro-4-pyridinecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: 97 percent / phosphoryl tribromide / dimethylformamide / 2 h / 130 °C

2.1: butyllithium; diisopropylamine / tetrahydrofuran; hexane / 2 h / -75 °C

2.2: 74 percent / tetrahydrofuran; hexane

With n-butyllithium; diisopropylamine; phosphorus(V) oxybromide; In tetrahydrofuran; hexane; N,N-dimethyl-formamide;
DOI:10.1002/1099-0690(200212)2002:24<4174::AID-EJOC4174>3.0.CO;2-6