514797-96-7

Usage

Uses

Used in Pharmaceutical Research:
2(1H)-Pyridinone,5-chloro-3-fluoro-(9CI) is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure and reactivity make it a valuable candidate for drug development, particularly in the context of novel therapeutic agents.
Used in Chemical Engineering:
2(1H)-Pyridinone,5-chloro-3-fluoro-(9CI) is employed as a reactant or catalyst in certain chemical processes, contributing to the production of other valuable chemicals or materials. Its specific properties, such as reactivity and stability, are harnessed to facilitate desired transformations in chemical engineering applications.
Used in Materials Science:
2(1H)-Pyridinone,5-chloro-3-fluoro-(9CI) is utilized in the development of new materials with tailored properties, such as advanced polymers or composites. Its incorporation into these materials can impart specific characteristics, such as improved mechanical strength, thermal stability, or chemical resistance, depending on the application.

InChI:InChI=1/C5H3ClFNO/c6-3-1-4(7)5(9)8-2-3/h1-2H,(H,8,9)

Upstream product

• 89402-43-7 5-chloro-2,3-difluoropyridine 

Downstream Products

• 514797-97-8 2-bromo-5-chloro-3-fluoro-pyridine 
• 1200498-46-9 5-cyano-3-fluoropyridine-2-carboxylic acid 
• 1200498-40-3 methyl 5-chloro-3-fluoropicolinate 
• 1200498-38-9 C₆H₂ClFNO₂^(1-)*Li⁽¹⁺⁾ 
• 514798-01-7 2-bromo-5-chloro-3-fluoro-4-pyridinecarboxylic acid 
• 514798-17-5 6-bromo-3-chloro-5-fluoro-2-pyridinecarboxylic acid 
• 514798-20-0 methyl 3-chloro-5-fluoro-6-iodo-2-pyridinecarboxylate 
• 514798-04-0 2,5-dichloro-3-fluoro-4-iodopyridine 
• 207994-08-9 5-chloro-3-fluoro-2-pyridinecarboxylic acid 
• 514798-03-9 3-chloro-5-fluoro-4-pyridinecarboxylic acid 
• 514798-11-9 3-chloro-5-fluoro-2-iodopyridine 
• 514797-98-9 5-chloro-3-fluoro-2-iodopyridine 
• 514798-07-3 3-chloro-5-fluoro-4-iodo-pyridine 
• 514797-99-0 3-chloro-5-fluoro-pyridine 

Relevant academic research and scientific papers

SULFUR-CONTAINING HETEROCYCLIC DERIVATIVE HAVING ?-SECRETASE-INHIBITING ACTIVITY

The following compound is provided as an agent for treating a disease induced by production, secretion and/or deposition of amyloid β protein, for example,. a compound represented by the formula (I): wherein ruing A is an optionally substituted carbocyclic group or an optionally substituted heterocyclic group, R1 is optionally substituted lower alkyl or the like, R2a and R2b are each independently hydrogen, optionally substituted lower alkyl or the like, R3a and R3c are each independently hydrogen, halogen, hydroxy, optionally substituted lower alkyl or the like, or a pharmaceutically acceptable salt thereof, or a solvate thereof.

Certain Chemical Entities, Compositions, and Methods

Provided are certain chemical entities, and methods of use to modulate skeletal myosin, skeletal actin, skeletal tropomyosin, skeletal troponin C, skeletal troponin I, skeletal troponin T, and skeletal muscle, including fragments and isoforms thereof, as well as the skeletal sarcomere, and methods of use in the treatment of muscle weakness and/or cachexia, as part of a rehabilitation or conditioning exercise regimen, or in the treatment of fraility, post-polio syndrome, obesity, sarcopenia, wasting syndrome, muscle spasm, and other indications.

Creating structural manifolds from a common precursor: Basicity gradient-driven isomerization of halopyridines

5-Chloro-2,3-difluoropyridine, an intermediate in the manufacturing process of an industrial pesticide, can be hydrolyzed to 5-chloro-3-fluoro-2H-pyridinone and the latter converted into 2,5-dichloro-3-fluoropyridine (1a), 2-bromo-5-chloro-3-fluoropyridine (1b), 5-chloro-3-fluoro-2-iodopyridine (1c) and 3-chloro-5-fluoropyridine (1d). Consecutive treatment of these four substrates with lithium diisopropylamide and carbon dioxide or lithium diisopropylamide and iodine affords the corresponding 4-pyridinecarboxylic acids 2 and 4-iodopyridines 3, respectively. Amide-promoted deprotonation of such 4-iodopyridines 3 triggers an isomerization in which lithium and iodine change places. The resulting species can be trapped with carbon dioxide to give the acids 5a-c or neutralized to give the halopyridines 4a-c. The iodopyridines 4a and 4b can be converted into the acids 6a and 6b, the latter product leading also to the congeners 6c and 6d. The diiodopyridine 4c provides an entry to the halopyridine 4d, which at the same time may act as the precursor to the acid 5d, the acid 7 or the bisacid 8. Finally, the acid 9 is accessible from either one of the 5-chloro-3-fluoro-2-halopyridines 1b and 1c. ( Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2002).