2-(3-Formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid

Base Information

Chemical Name:2-(3-Formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid
CAS No.:1312815-35-2
Molecular Formula:C₁₂H₉NO₄S
Molecular Weight:0
Hs Code.:

Synonyms:1312815-35-2;2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid;FeBuxostat Impurity 18;SCHEMBL2009745;BCP34203;A899108;2-(3-formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylicacid;2-(3-formyl-4-hydroxy phenyl)-4-methyl-thiazole-5-carboxylic acid

Suppliers and Price of 2-(3-Formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 9 raw suppliers

Chemical Property of 2-(3-Formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid

Chemical Property:

XLogP3:2.5
Hydrogen Bond Donor Count:2
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:3
Exact Mass:263.02522894
Heavy Atom Count:18
Complexity:338

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:CC1=C(SC(=N1)C2=CC(=C(C=C2)O)C=O)C(=O)O

Technology Process of 2-(3-Formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid

There total 1 articles about 2-(3-Formyl-4-hydroxyphenyl)-4-methylthiazole-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 886501-78-6
2-(4-hydroxy phenyl)-4-methyl-thiazole-5-carboxylic acid

: 100-97-0
hexamethylenetetramine

: 1312815-35-2
2-(3-formyl-4-hydroxy phenyl)-4-methyl-thiazole-5-carboxylic acid

Guidance literature:: 2-(4-hydroxy phenyl)-4-methyl-thiazole-5-carboxylic acid; hexamethylenetetramine; With methanesulfonic acid; at 80 - 85 ℃; for 6h;

With water; at 25 - 30 ℃;

Reference yield:

: 78-77-3
Isobutyl bromide

: 1312815-35-2
2-(3-formyl-4-hydroxy phenyl)-4-methyl-thiazole-5-carboxylic acid

: 1312815-36-3
2-(3-formyl-4-isobutyloxy phenyl)-4-methyl-thiazole-5-carboxylic acid isobutyl ester

Guidance literature:: With potassium carbonate; potassium iodide; In dimethyl sulfoxide; at 75 - 80 ℃; for 7h;

Reference yield:

: 1312815-35-2
2-(3-formyl-4-hydroxy phenyl)-4-methyl-thiazole-5-carboxylic acid

: 144060-53-7
febuxostat

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate; potassium iodide / dimethyl sulfoxide / 7 h / 75 - 80 °C

2.1: hydroxylamine hydrochloride; sodium formate / formic acid / 10 h / 99 - 100 °C

3.1: sodium hydroxide; ethanol / 4 h / Reflux

3.2: 1 h / 25 - 30 °C

With ethanol; hydroxylamine hydrochloride; sodium formate; potassium carbonate; potassium iodide; sodium hydroxide; In formic acid; dimethyl sulfoxide;