(R)-Tert-butyl 4-(2-hydroxyethyl)-2,2-dimethyloxazolidine-3-carboxylate

Base Information

Chemical Name:(R)-Tert-butyl 4-(2-hydroxyethyl)-2,2-dimethyloxazolidine-3-carboxylate
CAS No.:201404-86-6
Molecular Formula:C12H23NO4
Molecular Weight:245.32
Hs Code.:
DSSTox Substance ID:DTXSID50443160
Nikkaji Number:J1.154.965I
Wikidata:Q82260870
Mol file:201404-86-6.mol

Synonyms:201404-86-6;(R)-TERT-BUTYL 4-(2-HYDROXYETHYL)-2,2-DIMETHYLOXAZOLIDINE-3-CARBOXYLATE;Tert-butyl (4R)-4-(2-hydroxyethyl)-2,2-dimethyl-1,3-oxazolidine-3-carboxylate;(R)-N-BOC-4-(2-HYDROXYETHYL)-2,2-DIMETHYLOXAZOLIDINE;(R)-3-Boc-4-(2-hydroxyethyl)-2,2-dimethyloxazolidine;MFCD08234428;(R)-Tert-butyl4-(2-hydroxyethyl)-2,2-dimethyloxazolidine-3-carboxylate;SCHEMBL15318844;DTXSID50443160;XFA95918;AS-36017;CS-0449636;EN300-1664822;A909234;(4R)-2,2-Dimethyl-3-(tert-butoxycarbonyl)oxazolidine-4alpha-ethanol;(R)-Tert-butyl-4-(2-hydroxyethyl)-2,2-dimethyloxazolidine-3-carboxylate;Tert-butyl (R)-4-(2-hydroxyethyl)-2,2-dimethyloxazolidine-3-carboxylate

Suppliers and Price of (R)-Tert-butyl 4-(2-hydroxyethyl)-2,2-dimethyloxazolidine-3-carboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

AK Scientific
(R)-Tert-butyl4-(2-hydroxyethyl)-2,2-dimethyloxazolidine-3-carboxylate
5g
$ 1133.00

Activate Scientific
(R)-3-Boc-4-(2-hydroxyethyl)-2,2-dimethyloxazolidine 95+% ee
5 g
$ 1178.00

Total 9 raw suppliers

Chemical Property of (R)-Tert-butyl 4-(2-hydroxyethyl)-2,2-dimethyloxazolidine-3-carboxylate

Chemical Property:

Melting Point:75-76 °C
Boiling Point:330.0±27.0 °C(Predicted)
PKA:14.94±0.10(Predicted)
PSA：59.00000
Density:1.059±0.06 g/cm3(Predicted)
LogP:1.67870
XLogP3:1.2
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:4
Exact Mass:245.16270821
Heavy Atom Count:17
Complexity:283

Purity/Quality:

97% ^*data from raw suppliers

(R)-Tert-butyl4-(2-hydroxyethyl)-2,2-dimethyloxazolidine-3-carboxylate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC1(N(C(CO1)CCO)C(=O)OC(C)(C)C)C
Isomeric SMILES:CC1(N([C@@H](CO1)CCO)C(=O)OC(C)(C)C)C

Technology Process of (R)-Tert-butyl 4-(2-hydroxyethyl)-2,2-dimethyloxazolidine-3-carboxylate

There total 5 articles about (R)-Tert-butyl 4-(2-hydroxyethyl)-2,2-dimethyloxazolidine-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 77-76-9
2,2-dimethoxy-propane

: 397246-14-9,156627-42-8
(1-(hydroxymethyl)-3-hydroxypropyl)carbamic acid tert-butyl ester

: 201404-86-6
tert-butyl (4R)-4-(2-hydroxyethyl)-2,2-dimethyl-1,3-oxazolidine-3-carboxylate

Guidance literature:: With toluene-4-sulfonamide; In dichloromethane; at 20 ℃; for 3h; Concentration;

Reference yield: 96.0%

: 115378-31-9
tert-butyl (4R)-2,2-dimethyl-4-vinyloxazolidine-3-carboxylate

: 201404-86-6
tert-butyl (4R)-4-(2-hydroxyethyl)-2,2-dimethyl-1,3-oxazolidine-3-carboxylate

Guidance literature:: tert-butyl (4R)-2,2-dimethyl-4-vinyloxazolidine-3-carboxylate; With 9-borabicyclo[3.3.1]nonane dimer;

With sodium hydroxide; dihydrogen peroxide;
DOI:10.1016/S0040-4039(99)00997-1

Reference yield: 75.0%

: 102308-32-7
(4S)-4-formyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester

: pyrocatecholborane

: 18107-18-1
diazomethyl-trimethyl-silane

: 201404-86-6
tert-butyl (4R)-4-(2-hydroxyethyl)-2,2-dimethyl-1,3-oxazolidine-3-carboxylate

Guidance literature:: (4S)-4-formyl-2,2-dimethyl-oxazolidine-3-carboxylic acid tert-butyl ester; diazomethyl-trimethyl-silane; With triphenylphosphine; isopropyl alcohol; Wilkinson's catalyst; In tetrahydrofuran; at 20 ℃; for 2h;

pyrocatecholborane; In 1,4-dioxane;

With sodium hydroxide; dihydrogen peroxide; In 1,4-dioxane; at 20 ℃; for 3h;
DOI:10.1016/j.jorganchem.2005.03.058