1-Boc-2-[Methoxy(Methyl)carbaMoyl]pyrrolidine

Base Information

• Chemical Name: 1-Boc-2-[Methoxy(Methyl)carbaMoyl]pyrrolidine
• CAS No.: 334872-14-9
• Molecular Formula: C12H22N2O4
• Molecular Weight: 258.318
• Hs Code.: 2933998090
• Mol file: 334872-14-9.mol

Synonyms:1-Boc-2-[Methoxy(Methyl)carbaMoyl]pyrrolidine;2-(Methoxy-Methyl-Carbamoyl)-Pyrrolidine-1-Carboxylic Acid Tert-Butyl Ester

Chemical Property of 1-Boc-2-[Methoxy(Methyl)carbaMoyl]pyrrolidine

Chemical Property:

• PSA: 59.08000
• LogP: 1.34360

Purity/Quality:

NLT 98% ^*data from raw suppliers

tert-Butyl2-[Methoxy(methyl)carbamoyl]pyrrolidine-1-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Boc-2-[Methoxy(Methyl)carbaMoyl]pyrrolidine

There total 4 articles about 1-Boc-2-[Methoxy(Methyl)carbaMoyl]pyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) + N-tert-butoxycarbonyl-proline (15761-39-4,59433-50-0) → (S)-2-[(methoxymethylamino)carbonyl]-1-pyrrolidinecarboxylic acid 1,1-dimethylethyl ester (334872-14-9)

Guidance literature:

N-tert-butoxycarbonyl-proline; With 1,1'-carbonyldiimidazole; In dichloromethane; at 20 ℃; for 1h;

O,N-dimethyl-hydroxylamine hydrochloride; In dichloromethane; for 3h;

DOI:10.1039/d1ob02304g

Reference yield: 96.0%

1-(tert-butoxycarbonyl)-L-proline (15761-39-4,59433-50-0) + N,O-dimethylhydroxylamine*hydrochloride (6638-79-5) → (S)-2-[(methoxymethylamino)carbonyl]-1-pyrrolidinecarboxylic acid 1,1-dimethylethyl ester (334872-14-9)

Guidance literature:

1-(tert-butoxycarbonyl)-L-proline; N,O-dimethylhydroxylamine*hydrochloride; In dichloromethane; at 18 ℃; for 0.25h;

With tributylphosphine; (2-pyridine-N-oxide)disulfide; In dichloromethane;

DOI:10.1081/SCC-100104418

Reference yield: 86.0%

→ (S)-2-[(methoxymethylamino)carbonyl]-1-pyrrolidinecarboxylic acid 1,1-dimethylethyl ester (334872-14-9)

Guidance literature:

With 1,1'-carbonyldiimidazole; In dichloromethane; at 20 ℃; for 1.75h;

In dichloromethane; for 16h;

upstream raw materials:

1-(tert-butoxycarbonyl)-L-proline

N,O-dimethylhydroxylamine*hydrochloride

N-tert-butoxycarbonyl-proline

N,0-dimethylhydroxylamine

Downstream raw materials:

N-(tert-butoxycarbonyl)pyrrolidine-2-carboxaldehyde

tert-butyl 2-acetylpyrrolidine-1-carboxylate

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