2-[(2,5-dichloro-4-pyridinyl)amino]benzonitrile

Base Information

• Chemical Name: 2-[(2,5-dichloro-4-pyridinyl)amino]benzonitrile
• CAS No.: 1224887-80-2
• Molecular Formula: C₁₂H₇Cl₂N₃
• Molecular Weight: 264.114
• Mol file: 1224887-80-2.mol

Synonyms:2-[(2,5-dichloro-4-pyridinyl)amino]benzonitrile;2-(2,5-dichloropyridin-4-ylamino)benzonitrile

Chemical Property of 2-[(2,5-dichloro-4-pyridinyl)amino]benzonitrile

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

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Technology Process of 2-[(2,5-dichloro-4-pyridinyl)amino]benzonitrile

There total 2 articles about 2-[(2,5-dichloro-4-pyridinyl)amino]benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

anthranilic acid nitrile (1885-29-6) + 2,5-dichloro-4-iodo-pyridine (796851-03-1) → 2-[(2,5-dichloro-4-pyridinyl)amino]benzonitrile (1224887-80-2)

Guidance literature:

With potassium triphosphate; bis[2-(diphenylphosphino)phenyl] ether; palladium diacetate; In 1,4-dioxane; for 18h; Reflux;

Reference yield:

2,3,5-trichloropyridine (55934-01-5) + anthranilic acid nitrile (1885-29-6) → 2-[(2,5-dichloro-4-pyridinyl)amino]benzonitrile (1224887-80-2)

Guidance literature:

With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 130 ℃; for 1h; regiospecific reaction; Microwave irradiation;

DOI:10.1016/j.bmcl.2011.09.090

Reference yield: 52.4%

2-[(2,5-dichloro-4-pyridinyl)amino]benzonitrile (1224887-80-2) + 3-methyl-1-(1-methylethyl)-1H-pyrazol-5-amine (1124-16-9) → 2-[(5-chloro-2-{[3-methyl-1-(1-methylethyl)-1H-pyrazol-5-yl]amino}-4-pyridinyl)a mino]benzonitrile (1224887-82-4)

Guidance literature:

With caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium diacetate; In 1,4-dioxane; Reflux;

upstream raw materials:

anthranilic acid nitrile

2,5-dichloro-4-iodo-pyridine

2,3,5-trichloropyridine

Downstream raw materials:

2-({5-chloro-2-[(1-ethyl-3-methyl-1H-pyrazol-5-yl)amino]-4-pyridinyl}amino)benzonitrile

2-[(5-chloro-2-{[3-methyl-1-(1-methylethyl)-1H-pyrazol-5-yl]amino}-4-pyridinyl)a mino]benzonitrile

C₁₉H₁₆ClN₃O₃

2-[(5-chloro-2-{[3-methyl-1-(1-methylethyl)-1H-pyrazol-5-yl]amino}-4-pyridinyl)amino]benzoic acid

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