1-Ethyl-6-fluorobenzoimidazole

Base Information

• Chemical Name: 1-Ethyl-6-fluorobenzoimidazole
• CAS No.: 1187385-87-0
• Molecular Formula: C₉H₉FN₂
• Molecular Weight: 164.182
• Hs Code.: 2933990090
• Mol file: 1187385-87-0.mol

Synonyms:1-Ethyl-6-fluorobenzoimidazole;1-Ethyl-6-fluoro-1H-benzo[d]imidazole

Chemical Property of 1-Ethyl-6-fluorobenzoimidazole

Chemical Property:

• PSA: 17.82000
• LogP: 2.19530

Purity/Quality:

97% ^*data from raw suppliers

1-Ethyl-6-fluorobenzoimidazole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-Ethyl-6-fluorobenzoimidazole

There total 4 articles about 1-Ethyl-6-fluorobenzoimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

formic acid (64-18-6) + 4-nitro-3-N-ethylamino-1-fluorobenzene (475278-46-7) → 1-ethyl-6-fluoro-1H-benzo[d]imidazole (1187385-87-0)

Guidance literature:

With iron; ammonium chloride; In isopropyl alcohol; for 12h; Reflux;

Reference yield:

formic acid (64-18-6) + N1-ethyl-5-fluorobenzene-1,2-diamine → 1-ethyl-6-fluoro-1H-benzo[d]imidazole (1187385-87-0)

Guidance literature:

at 100 ℃; for 16h; Inert atmosphere;

Reference yield:

2,4-Difluoronitrobenzene (446-35-5) → 1-ethyl-6-fluoro-1H-benzo[d]imidazole (1187385-87-0)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / acetonitrile / 16 h / 20 °C

2: iron; ammonium chloride / isopropyl alcohol / 12 h / Reflux

With iron; potassium carbonate; ammonium chloride; In isopropyl alcohol; acetonitrile;

upstream raw materials:

2,4-Difluoronitrobenzene

formic acid

4-nitro-3-N-ethylamino-1-fluorobenzene