diethyl 1-[2-(2,4-dichlorophenyl)-2-oxoethyl]-1H-pyrazole-3,5-dicarboxylate

Base Information

Chemical Name:diethyl 1-[2-(2,4-dichlorophenyl)-2-oxoethyl]-1H-pyrazole-3,5-dicarboxylate
CAS No.:1101323-82-3
Molecular Formula:C17H16Cl2N2O5
Molecular Weight:399.23
Hs Code.:
Mol file:1101323-82-3.mol

Synonyms:diethyl 1-[2-(2,4-dichlorophenyl)-2-oxoethyl]-1H-pyrazole-3,5-dicarboxylate

Suppliers and Price of diethyl 1-[2-(2,4-dichlorophenyl)-2-oxoethyl]-1H-pyrazole-3,5-dicarboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of diethyl 1-[2-(2,4-dichlorophenyl)-2-oxoethyl]-1H-pyrazole-3,5-dicarboxylate

Chemical Property:

PSA：87.49000
LogP:3.42620

Purity/Quality:

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Technology Process of diethyl 1-[2-(2,4-dichlorophenyl)-2-oxoethyl]-1H-pyrazole-3,5-dicarboxylate

There total 1 articles about diethyl 1-[2-(2,4-dichlorophenyl)-2-oxoethyl]-1H-pyrazole-3,5-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 2631-72-3
2,4-dichlorophenacyl bromide

: 37687-24-4
diethyl 1H-pyrazole-3,5-dicarboxylate

: 1101323-82-3
diethyl 1-[2-(2,4-dichlorophenyl)-2-oxoethyl]-1H-pyrazole-3,5-dicarboxylate

Guidance literature:: With potassium carbonate; In acetone; at 20 ℃; for 12h;

Reference yield: 82.0%

: 1101323-82-3
diethyl 1-[2-(2,4-dichlorophenyl)-2-oxoethyl]-1H-pyrazole-3,5-dicarboxylate

: 1101323-84-5
ethyl 6-(2,4-dichlorophenyl)-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazine-2-carboxylate

Guidance literature:: diethyl 1-[2-(2,4-dichlorophenyl)-2-oxoethyl]-1H-pyrazole-3,5-dicarboxylate; With ammonium acetate; acetic acid; for 12h; Reflux;

With sodium carbonate; In water;

Reference yield:

: 1101323-82-3
diethyl 1-[2-(2,4-dichlorophenyl)-2-oxoethyl]-1H-pyrazole-3,5-dicarboxylate

: 1101324-49-5
6-(2,4-dichlorophenyl)-4-oxo-4,5-dihydropyrazolo[1,5-a]pyrazine-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: ammonium acetate; acetic acid / 12 h / Reflux

2.1: sodium hydroxide / 1,2-dimethoxyethane / 3 h / 20 °C

2.2: pH 3

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; ammonia / dmap / dichloromethane; N,N-dimethyl-formamide; 1,4-dioxane / 20 h / 20 °C

With ammonium acetate; ammonia; benzotriazol-1-ol; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; sodium hydroxide; dmap; In 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; N,N-dimethyl-formamide;