Vinpocetine

Base Information

• Chemical Name: Vinpocetine
• CAS No.: 80038-06-8
• Molecular Formula: C₂₂H₂₆N₂O₂
• Molecular Weight: 350.461
• Mol file: 80038-06-8.mol

Synonyms:(+)-Apovincaminic acid ethyl ester; (+)-cis-Apovincaminic acid ethyl ester; 3-alpha,16-alpha-Apovincaminic acid ethyl ester; AY 27,255; Apovincaminate d'ethyle; Apovincaminate d'ethyle [French]; Apovincaminic acid ethyl ester; BRN 0900803; Cavinton; Ethyl (+)-apovincaminate; Ethyl (+)-cis-apovincaminate; Ethyl apovincamin-22-oate; RGH 4405; RGH-4405; TCV-3B; UNII-543512OBTC; Vinpocetinum; Vinpocetinum [INN-Latin]; cis-Apovincaminic acid ethyl ester; Eburnamenine-14-carboxylic acid, ethyl ester, (3-alpha,16-alpha)-; Eburnamenine-14-carboxylic acid, ethyl ester, (3alpha,16alpha)-; ethyl eburnamenine-14-carboxylate; ethyl (3alpha,16alpha)-eburnamenine-14-carboxylate; (3alpha,16alpha)-14-(ethoxycarbonyl)eburnamenin-4-ium

Chemical Property of Vinpocetine

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 419.5°C at 760 mmHg
• Flash Point: 207.506°C

Purity/Quality:

99%, ^*data from raw suppliers

Safty Information:

• Hazard Codes: Xn:Harmful
• Statements: R22:
• Safety Statements: S36:

MSDS Files:

Useful:

Technology Process of Vinpocetine

There total 58 articles about Vinpocetine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

ethanol (64-17-5) + apovincamine (4880-92-6) → Vinpocetine (42971-09-5,80038-06-8)

Guidance literature:

With titanium(IV) tetraethanolate; In 1,4-dioxane; for 40h; Heating;

DOI:10.1080/00397919408011297

Reference yield: 90.0%

sodium ethanolate (141-52-6) + apovincamine (4880-92-6) → Vinpocetine (42971-09-5,80038-06-8)

Guidance literature:

In ethanol; toluene; for 0.0166667h; Heating;

Reference yield: 83.0%

3-((1S,12bS)-1-Ethyl-1,2,3,4,6,7,12,12b-octahydro-indolo[2,3-a]quinolizin-1-yl)-2-[(E)-hydroxyimino]-propionic acid ethyl ester (89396-73-6) → Vinpocetine (42971-09-5,80038-06-8)

Guidance literature:

In ethanol; sulfuric acid; for 0.5h; Heating;

DOI:10.1016/S0040-4020(01)88614-2

upstream raw materials:

ethanol

(3S,17S)-14-oxo-15-hydroxyimino-E-homoeburnane

vincamin

3-((1S,12bS)-1-Ethyl-1,2,3,4,6,7,12,12b-octahydro-indolo[2,3-a]quinolizin-1-yl)-2-[(E)-hydroxyimino]-propionic acid ethyl ester