4-[(4-Chlorophenyl)Phenylmethyl]-1-Piperazineethanol Hydrochloride

Base Information

• Chemical Name: 4-[(4-Chlorophenyl)Phenylmethyl]-1-Piperazineethanol Hydrochloride
• CAS No.: 1177093-13-8
• Molecular Formula: C₁₉H₂₃ClN₂O*ClH
• Molecular Weight: 367.318
• Hs Code.: 2933599090
• Mol file: 1177093-13-8.mol

Synonyms:4-[(4-Chlorophenyl)Phenylmethyl]-1-Piperazineethanol Hydrochloride

Chemical Property of 4-[(4-Chlorophenyl)Phenylmethyl]-1-Piperazineethanol Hydrochloride

Chemical Property:

• PSA: 26.71000
• LogP: 3.71710

Purity/Quality:

4-[(4-Chlorophenyl)phenylmethyl]-1-piperazineethanol hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-[(4-Chlorophenyl)Phenylmethyl]-1-Piperazineethanol Hydrochloride

There total 8 articles about 4-[(4-Chlorophenyl)Phenylmethyl]-1-Piperazineethanol Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

N-(4-chlorobenzhydryl)piperazine (303-26-4) + 2-chloro-ethanol (107-07-3) → 2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol dihydrochloride (1177093-13-8,728948-88-7)

Guidance literature:

N-(4-chlorobenzhydryl)piperazine; 2-chloro-ethanol; With sodium carbonate; potassium iodide; In isopropyl alcohol; for 24h; Reflux;

With hydrogenchloride; In isopropyl alcohol; at 20 - 25 ℃;

Reference yield:

2-chloro-ethanol (107-07-3) + (R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine (300543-56-0) → C19H23ClN2O*ClH (1177093-13-8,728948-88-7)

Guidance literature:

2-chloro-ethanol; (R)-1-((4-chlorophenyl)(phenyl)methyl)piperazine; With triethylamine; In toluene; at 110 - 115 ℃; for 7h;

With hydrogenchloride; In water; acetone; at 25 - 30 ℃; for 12h;

Reference yield:

1-(2-hydroxyethyl)piperazine (103-76-4) + 1-chloro-4-(chloro(phenyl)methyl)benzene (134-83-8,60035-71-4) → 2-{4-[(4-chlorophenyl)(phenyl)methyl]piperazin-1-yl}ethan-1-ol dihydrochloride (1177093-13-8,728948-88-7)

Guidance literature:

1-(2-hydroxyethyl)piperazine; 1-chloro-4-(chloro(phenyl)methyl)benzene; In toluene; at 80 ℃; for 3h; Large scale reaction;

With hydrogenchloride; water; In isopropyl alcohol; pH=1; Large scale reaction;

DOI:10.1021/op300009y

upstream raw materials:

N-(4-chlorobenzhydryl)piperazine

2-chloro-ethanol

1-(2-hydroxyethyl)piperazine

1-chloro-4-(chloro(phenyl)methyl)benzene

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