Indolizine, octahydro-8-methoxy-1,6,7-tris(phenylmethoxy)-, 1S-(1.alpha.,6.beta.,7.alpha.,8.beta.,8a.beta.)-

Base Information

• Chemical Name: Indolizine, octahydro-8-methoxy-1,6,7-tris(phenylmethoxy)-, 1S-(1.alpha.,6.beta.,7.alpha.,8.beta.,8a.beta.)-
• CAS No.: 171925-42-1
• Molecular Formula: C₃₀H₃₅NO₄
• Molecular Weight: 473.612
• Mol file: 171925-42-1.mol

Synonyms:Indolizine, octahydro-8-methoxy-1,6,7-tris(phenylmethoxy)-, 1S-(1.alpha.,6.beta.,7.alpha.,8.beta.,8a.beta.)-

Chemical Property of Indolizine, octahydro-8-methoxy-1,6,7-tris(phenylmethoxy)-, 1S-(1.alpha.,6.beta.,7.alpha.,8.beta.,8a.beta.)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Indolizine, octahydro-8-methoxy-1,6,7-tris(phenylmethoxy)-, 1S-(1.alpha.,6.beta.,7.alpha.,8.beta.,8a.beta.)-

There total 1 articles about Indolizine, octahydro-8-methoxy-1,6,7-tris(phenylmethoxy)-, 1S-(1.alpha.,6.beta.,7.alpha.,8.beta.,8a.beta.)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(1S,6S,7R,8R,8aR)-2,6,7,8-tetrahydroxy-indolizidine (79831-76-8) + benzyl bromide (100-39-0) + methyl iodide (74-88-4) → 1,6,7-tri-O-benzyl-8-O-methylcastanospermine (171925-42-1) + 1,2,7-tri-O-benzyl-8-O-methyl-1(R),2(S)7(S),8(R),8a(R)-tetrahydroxyoctahydroindolizidine (171925-43-2)

Guidance literature:

With 1-thiopropane; tetrabutylammomium bromide; sodium hydride; di(n-butyl)tin oxide; Yield given. Multistep reaction. Yields of byproduct given; 1.) MePh, reflux, 2 h, 2.) MePh, reflux, 3 days, 3.) DMSO, 4.) DMSO;

DOI:10.1016/0040-4020(95)00803-G

Reference yield: 85.0%

1,6,7-tri-O-benzyl-8-O-methylcastanospermine (171925-42-1) → 8-O-methylcastanospermine (171925-44-3)

Guidance literature:

With hydrogen; palladium dihydroxide; In acetic acid; for 48h; under 2068.6 Torr;

DOI:10.1016/0040-4020(95)00803-G

upstream raw materials:

(1S,6S,7R,8R,8aR)-2,6,7,8-tetrahydroxy-indolizidine

benzyl bromide

methyl iodide

Downstream raw materials:

8-O-methylcastanospermine

Refernces