Tibolone 3-Dimethyl Ketal

Base Information

• Chemical Name: Tibolone 3-Dimethyl Ketal
• CAS No.: 105186-33-2
• Molecular Formula: C23H34O3
• Molecular Weight: 358.521
• Mol file: 105186-33-2.mol

Synonyms:Tibolone 3-Dimethyl Ketal;(7alpha,17alpha)-3,3-Dimethoxy-7-methyl-19-norpregn-5(10)-en-20-yn-17-ol

Chemical Property of Tibolone 3-Dimethyl Ketal

Chemical Property:

• PSA: 35.53000
• LogP: 4.50740
• Storage Temp.: Amber Vial, -20°C Freezer, Under inert atmosphere
• Solubility.: Acetonitrile (Slightly), Chloroform (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

Tibolone3-DimethylKetal ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Tibolone intermediate.

Technology Process of Tibolone 3-Dimethyl Ketal

There total 6 articles about Tibolone 3-Dimethyl Ketal which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

3,3-dimethoxy-7α-methylestr-5(10)-en-17-one (88247-84-1) + acetylene (74-86-2,25067-58-7) → 3,3-dimethoxy-7α-methyl-19-nor-17α-pregn-5(10)-en-20-yn-17β-ol (105186-33-2)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; at 0 ℃; for 2h;

DOI:10.1002/recl.19861050403

Reference yield:

methanol (67-56-1) + 7α-methyl-17α-ethinyl-17β-hydroxy-4-estren-3-one (1162-60-3) → 3,3-dimethoxy-7α-methyl-19-nor-17α-pregn-5(10)-en-20-yn-17β-ol (105186-33-2)

Guidance literature:

With boron trifluoride diethyl etherate; Pyridine hydrobromide; at 40 ℃; Reagent/catalyst; Temperature; Inert atmosphere;

Reference yield:

6,7-dehydro norethindrone → 3,3-dimethoxy-7α-methyl-19-nor-17α-pregn-5(10)-en-20-yn-17β-ol (105186-33-2)

Guidance literature:

Multi-step reaction with 2 steps

1: copper(l) chloride / tetrahydrofuran / -20 °C / Inert atmosphere

2: Pyridine hydrobromide; boron trifluoride diethyl etherate / 40 °C / Inert atmosphere

With boron trifluoride diethyl etherate; Pyridine hydrobromide; copper(l) chloride; In tetrahydrofuran;

upstream raw materials:

3,3-dimethoxy-7α-methylestr-5(10)-en-17-one

acetylene

7α-methylestr-5(10)-ene-3,17-dione

7α-methyl-3,17-dioxoandrost-4-en-19-al

Downstream raw materials:

7α-methyl-17α-ethinyl-17β-hydroxy-4-estren-3-one

tibolone

10β-hydroperoxy-17β-hydroxy-7α-methyl-19-nor-17α-pregn-4-en-20-yn-3-one

10β,17β-dihydroxy-7α-methyl-19-nor-17α-pregn-4-en-20-yn-3-one