350014-18-5

Upstream product

• 67-56-1 methanol 
• 38449-59-1 2-(3-hydroxyphenyl)ethylamine hydrobromide 
• 298-12-4 Glyoxilic acid 
• 2039-67-0 2-(3-methoxyphenyl)-1-ethanamine 
• 91523-50-1 rac-6-hydroxy-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid 
• 75-36-5 acetyl chloride 
• 100-83-4 meta-hydroxybenzaldehyde 
• 24550-32-1 1-(benzyloxy)-3-[(E)-2-nitroethenyl]benzene 
• 1700-37-4 3-Benzyloxybenzaldehyde 
• 588-05-6 m-tyramine 

Downstream Products

• 350014-19-6 methyl N-(tert-butyloxycarbonyl)-6-hydroxy-3,4-dihydro-1H-isoquinoline-1-carboxylate 
• 373638-26-7 C₁₉H₁₉NO₅ 
• 174299-07-1 6-hydroxy-isoquinoline-1-carboxylic acid 
• 531554-36-6 C₂₈H₃₉N₃O₃ 
• 373634-03-8 C₂₉H₃₃N₃O₄ 
• 373638-23-4 1-[[[(R)-2-[bis(1-methylethyl)amino]ethyl]amino]carbonyl]-3,4-dihydro-6-(phenylmethoxy)-2-(1H)-isoquinoline-carboxylic acid 1,1-dimethylethyl ester 
• 373633-80-8 1-[[[(S)-2-[bis(1-methylethyl)amino]ethyl]amino]carbonyl]-3,4-dihydro-6-(phenylmethoxy)-2-(1H)-isoquinoline-carboxylic acid 1,1-dimethylethyl ester 
• 531553-76-1 C₃₅H₃₇N₃O₃ 
• 373633-79-5 1-[[[2-[bis(1-methylethyl)amino]ethyl]amino]carbonyl]-3,4-dihydro-6-(phenylmethoxy)-2-(1H)-isoquinoline-carboxylic acid 1,1-dimethylethyl ester methanesulfonate 
• 373636-62-5 C₂HF₃O₂*C₃₂H₃₉N₃O₃ 
• 373634-23-2 C₂HF₃O₂*C₃₀H₄₃N₃O₄ 
• 373637-03-7 C₂HF₃O₂*C₃₂H₄₀N₄O₃ 
• 373634-41-4 C₂HF₃O₂*C₃₁H₄₃N₃O₆ 
• 373634-57-2 C₂HF₃O₂*C₃₂H₄₅N₃O₄ 

Relevant academic research and scientific papers

Synthesis of novel (benzimidazolyl)isoquinolinols and evaluation as adenosine A1 receptor tools

G protein-coupled receptors (GPCRs) constitute the largest family of transmembrane receptors in eukaryotes. The adenosine A1 receptor (A1AR) is a class A GPCR that is of interest as a therapeutic target particularly in the treatment of cardiovascular disease and neuropathic pain. Increased knowledge of the role A1AR plays in mediating these pathophysiological processes will help realise the therapeutic potential of this receptor. There is a lack of enabling tools such as selective fluorescent probes to study A1AR, therefore we designed a series of (benzimidazolyl)isoquinolinols conjugated to a fluorescent dye (31-35, 42-43). An improved procedure for the synthesis of isoquinolinols from tetrahydroisoquinolinols via oxidation with 2,3-dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) and atmospheric oxygen is reported. This synthetic method offers advantages over previous metal-based methods for the preparation of isoquinolinols and isoquinolines, which are important scaffolds found in many biologically active compounds and natural products. We report the first synthesis of the (benzimidazolyl)isoquinolinol compound class, however the fluorescent conjugates were not successful as A1AR fluorescent ligands.

Tetrahydroisoquinoline 1-carboxamides as growth hormone secretagogues

Several novel series of tetrahydroisoquinoline 1-carboxamides were prepared and shown to be potent growth hormone (GH) secretagogues. Among them, carbamate 12a-E2 displays excellent in vivo activity by increasing plasma GH 10-fold in an anesthetized IV rat model.

Tetrahydroisoquinoline based sulfonamide hydroxamates as potent matrix metalloproteinase inhibitors

The synthesis and MMP inhibitory activity of a series of tetrahydroisoquinoline based sulfonamide hydroxamates are described. In nine MMPs tested, most of the compounds display potent inhibition activity except for MMP-7. Some subtle isozyme selectivity is observed by varying the substituents at the 6- and 7-positions and aromatic ring of arylsulfonyl groups.

Tetrahydroisoquinoline analogs as modulators of chemokine receptor activity

Tetrahydroisoquinoline analogs are provided which are modulators of chemokine receptor activity. The tetrahdroisoquinoline analogs thereof have the structure wherein R1, R2, R3, R3a, X1, X2, X3, X4, m, n and p are as described herein.

Lactam derivatives as antiarrhythmic agents

Lactam derivatives of the formula where X is —C(═O)NR3′—, —NR3′C(═O)—, —C(═NCN)NR3′—, —NR3′C(═NCN)—, —CH2NR3′—, —CH(alkyl)NR3′—, —CH(COOalkyl)NR3′—, —CH(CH2