BIS-(4-FLUORO-PHENYL)-PHENYL-ACETONITRILE

Base Information

• Chemical Name: BIS-(4-FLUORO-PHENYL)-PHENYL-ACETONITRILE
• CAS No.: 289656-82-2
• Molecular Formula: C₂₀H₁₃F₂N
• Molecular Weight: 305.327
• Mol file: 289656-82-2.mol

Synonyms:BIS-(4-FLUORO-PHENYL)-PHENYL-ACETONITRILE;Benzeneacetonitrile, 4-fluoro-a-(4-fluorophenyl)-a-phenyl-

Chemical Property of BIS-(4-FLUORO-PHENYL)-PHENYL-ACETONITRILE

Chemical Property:

• Vapor Pressure: 2.83E-06mmHg at 25°C
• Boiling Point: 389.5°C at 760 mmHg
• Flash Point: 189.4°C
• PSA: 23.79000
• Density: 1.215g/cm³
• LogP: 4.82278
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

2,2-Bis(4-fluorophenyl)-2-phenylacetonitrile 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of BIS-(4-FLUORO-PHENYL)-PHENYL-ACETONITRILE

There total 5 articles about BIS-(4-FLUORO-PHENYL)-PHENYL-ACETONITRILE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 67.0%

bis(4-fluorophenyl)phenylchloromethane (379-54-4) + copper(I) cyanide (544-92-3) → bis(4-fluorophenyl)phenylacetonitrile (289656-82-2)

Guidance literature:

In toluene; at 100 - 140 ℃; for 3.16667h;

Reference yield: 67.0%

bis(4-fluorophenyl)phenylmethanol (379-55-5) + acetyl chloride (75-36-5) → bis(4-fluorophenyl)phenylacetonitrile (289656-82-2)

Guidance literature:

In hexane; dichloromethane; toluene;

Reference yield:

phenylmagnesium bromide (100-58-3) → bis(4-fluorophenyl)phenylacetonitrile (289656-82-2)

Guidance literature:

Multi-step reaction with 2 steps

1.1: toluene; tetrahydrofuran / 20 - 50 °C / Large scale

2.1: indium(III) chloride / toluene / 0.5 h / 20 °C / Large scale

2.2: 2.5 h / 20 - 40 °C / Large scale

With indium(III) chloride; In tetrahydrofuran; toluene;

DOI:10.1021/op3000916

upstream raw materials:

bis(4-fluorophenyl)phenylmethanol

acetyl chloride

bis(4-fluorophenyl)phenylchloromethane

copper(I) cyanide

Downstream raw materials:

Senicapoc

bis-(4-fluoro-phenyl)-phenyl-methane

C₂₀H₁₄F₂O₂