2-(4-Ethylpiperazin-1-yl)ethanamine

Base Information

• Chemical Name: 2-(4-Ethylpiperazin-1-yl)ethanamine
• CAS No.: 4489-46-7
• Molecular Formula: C8H19N3
• Molecular Weight: 157.259
• Hs Code.: 2933599090
• European Community (EC) Number: 837-628-7
• DSSTox Substance ID: DTXSID50354580
• Wikidata: Q82132810
• ChEMBL ID: CHEMBL3959853
• Mol file: 4489-46-7.mol

Synonyms:2-(4-ethylpiperazin-1-yl)ethanamine;4489-46-7;2-(4-Ethyl-piperazin-1-yl)-ethylamine;2-(4-ethylpiperazin-1-yl)ethan-1-amine;2-(4-ethyl-1-piperazinyl)ethanamine;1-piperazineethanamine, 4-ethyl-;ChemDiv2_003369;1-piperazineethanamine,4-ethyl-;1-Piperazineethanamine,4-ethyl-(9CI);EC-000.1995;Oprea1_001119;SCHEMBL246702;CHEMBL3959853;DTXSID50354580;SHUQIGHJQMJUHB-UHFFFAOYSA-N;HMS1378J03;STR07559;4-(2-aminoethyl)-1-ethylpiperazine;MFCD03021426;STK503373;AKOS000145538;BB 0260021;CS-0216174;EU-0033332;FT-0676728;EN300-35767;A872456;2-(4-Ethyl-piperazin-1-yl)-ethylamine, AldrichCPR;F2187-2202;Z271005886

Chemical Property of 2-(4-Ethylpiperazin-1-yl)ethanamine

Chemical Property:

• Vapor Pressure: 0.0452mmHg at 25°C
• Boiling Point: 237.3°C at 760 mmHg
• Flash Point: 96.3°C
• PSA: 32.50000
• Density: 0.939g/cm³
• LogP: 0.15870
• XLogP3: -0.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 157.157897619
• Heavy Atom Count: 11
• Complexity: 97.5

Purity/Quality:

98%min ^*data from raw suppliers

2-(4-Ethylpiperazin-1-yl)ethanamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCN1CCN(CC1)CCN

Technology Process of 2-(4-Ethylpiperazin-1-yl)ethanamine

There total 4 articles about 2-(4-Ethylpiperazin-1-yl)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-(2-hydroxyethyl)piperazine (103-76-4) + cobalt chloride + cyanomethyl bromide (590-17-0) → 2-(4-ethylpiperazin-1-yl)ethan-1-amine (4489-46-7)

Guidance literature:

With sodium borohydrid; potassium carbonate; In methanol; chloroform; acetone;

Reference yield:

(4-ethyl-piperazin-1-yl)-acetonitrile (90206-22-7) → 2-(4-ethylpiperazin-1-yl)ethan-1-amine (4489-46-7)

Guidance literature:

With sodium hydroxide; nickel; under 29420.3 - 36775.4 Torr; Hydrogenation;

Reference yield:

4-ethylpiperazine (5308-25-8) → 2-(4-ethylpiperazin-1-yl)ethan-1-amine (4489-46-7)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol

2: sodium hydroxide; nickel / 29420.3 - 36775.4 Torr / Hydrogenation

With sodium hydroxide; ethanol; nickel;

upstream raw materials:

(4-ethyl-piperazin-1-yl)-acetonitrile

4-ethylpiperazine

1-(2-hydroxyethyl)piperazine

cyanomethyl bromide

Downstream raw materials:

2-(4-isobutyl-piperazin-1-yl)-ethylamine

2-[1-(4-cyanophenyl)-7-methoxy-3-methyl-3H-pyrazolo[3,4-c]-quinolin-8-yloxy]-N-[2-(4-ethylpiperazin-1-yl)ethyl]-2-(4-fluorophenyl)acetamide

Refernces

• 1、 -. "Alkylenediamine derivative anti-ulcer drug and antibacterial drug". . . Retrieved 2008/06/13.