Technology Process of 2,4-dichloro-5-phenylquinazoline
There total 4 articles about 2,4-dichloro-5-phenylquinazoline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 3 steps
1: acetic acid / water / 35 °C
2: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium(0) / 1,2-dimethoxyethane; water / 40 h / Reflux
3: trichlorophosphate; N,N-dimethyl-aniline / 2 h / 105 °C
With
sodium hydrogencarbonate; acetic acid; N,N-dimethyl-aniline; trichlorophosphate;
tetrakis(triphenylphosphine) palladium(0);
In
1,2-dimethoxyethane; water;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydroxide; dihydrogen peroxide / 1.25 h / 80 °C
1.2: pH 4 - 5
2.1: acetic acid / water / 35 °C
3.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium(0) / 1,2-dimethoxyethane; water / 40 h / Reflux
4.1: trichlorophosphate; N,N-dimethyl-aniline / 2 h / 105 °C
With
dihydrogen peroxide; sodium hydrogencarbonate; acetic acid; N,N-dimethyl-aniline; sodium hydroxide; trichlorophosphate;
tetrakis(triphenylphosphine) palladium(0);
In
1,2-dimethoxyethane; water;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium(0) / 1,2-dimethoxyethane; water / 40 h / Reflux
2: trichlorophosphate; N,N-dimethyl-aniline / 2 h / 105 °C
With
sodium hydrogencarbonate; N,N-dimethyl-aniline; trichlorophosphate;
tetrakis(triphenylphosphine) palladium(0);
In
1,2-dimethoxyethane; water;
