methyl 4-((2-chloro-5-phenylquinazolin-4-ylamino)methyl)benzoate

Base Information

Chemical Name:methyl 4-((2-chloro-5-phenylquinazolin-4-ylamino)methyl)benzoate
CAS No.:1272356-79-2
Molecular Formula:C₂₃H₁₈ClN₃O₂
Molecular Weight:0
Hs Code.:
Mol file:1272356-79-2.mol

Synonyms:methyl 4-((2-chloro-5-phenylquinazolin-4-ylamino)methyl)benzoate

Suppliers and Price of methyl 4-((2-chloro-5-phenylquinazolin-4-ylamino)methyl)benzoate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 1 raw suppliers

Chemical Property of methyl 4-((2-chloro-5-phenylquinazolin-4-ylamino)methyl)benzoate

Chemical Property:

Purity/Quality:: 98%min ^*data from raw suppliers

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Technology Process of methyl 4-((2-chloro-5-phenylquinazolin-4-ylamino)methyl)benzoate

There total 6 articles about methyl 4-((2-chloro-5-phenylquinazolin-4-ylamino)methyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 18469-52-8
methyl 4-(aminomethyl)benzoate

: 1272356-64-5
2,4-dichloro-5-phenylquinazoline

: 1272356-79-2
methyl 4-((2-chloro-5-phenylquinazolin-4-ylamino)methyl)benzoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; for 12h;

Reference yield:

: 959237-01-5
5-bromoquinazoline-2,4(1H,3H)-dione

: 1272356-79-2
methyl 4-((2-chloro-5-phenylquinazolin-4-ylamino)methyl)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 40 h / Reflux

2: trichlorophosphate; N,N-dimethyl-aniline / 2 h / 105 °C

3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 12 h

With sodium hydrogencarbonate; N,N-dimethyl-aniline; N-ethyl-N,N-diisopropylamine; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; water;

Reference yield:

: 20780-72-7
4-bromoisatin

: 1272356-79-2
methyl 4-((2-chloro-5-phenylquinazolin-4-ylamino)methyl)benzoate

Guidance literature:: Multi-step reaction with 5 steps

1.1: sodium hydroxide; dihydrogen peroxide / 1.25 h / 80 °C

1.2: pH 4 - 5

2.1: acetic acid / water / 35 °C

3.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 40 h / Reflux

4.1: trichlorophosphate; N,N-dimethyl-aniline / 2 h / 105 °C

5.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 12 h

With dihydrogen peroxide; sodium hydrogencarbonate; acetic acid; N,N-dimethyl-aniline; N-ethyl-N,N-diisopropylamine; sodium hydroxide; trichlorophosphate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,2-dimethoxyethane; water;