19861-62-2Relevant academic research and scientific papers
Optimization of 2,4-diarylanilines as non-nucleoside HIV-1 reverse transcriptase inhibitors
Sun, Lian-Qi,Qin, Bingjie,Huang, Li,Qian, Keduo,Chen, Chin-Ho,Lee, Kuo-Hsiung,Xie, Lan
scheme or table, p. 2376 - 2379 (2012/05/05)
The current optimization of 2,4-diarylaniline analogs (DAANs) on the central phenyl ring provided a series of new active DAAN derivatives 9a-9e, indicating an accessible modification approach that could improve anti-HIV potency against wild-type and resis
Design, synthesis, and preclinical evaluations of novel 4-substituted 1,5-diarylanilines as potent HIV-1 non-nucleoside reverse transcriptase inhibitor (NNRTI) drug candidates
Sun, Lian-Qi,Zhu, Lei,Qian, Keduo,Qin, Bingjie,Huang, Li,Chen, Chin Ho,Lee, Kuo-Hsiung,Xie, Lan
, p. 7219 - 7229 (2012/11/07)
Twenty-one new 4-substituted diarylaniline compounds (DAANs) (series 13, 14, and 15) were designed, synthesized, and evaluated against wildtype and drug resistant HIV-1 viral strains. As a result, approximately a dozen new DAANs showed high potency with l
QUINAZOLINONE COMPOUNDS
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Page/Page column 29-30, (2010/07/09)
The present invention relates to quinazolinone compounds, processes for their preparation and their use as pharmaceutical agents for the treatment of Parkinson's disease (PD). The quinazolinone compounds are of general formula (I).
Synthesis and antimycobacterial activities of novel 6-nitroquinolone-3-carboxylic acids
Senthilkumar, Palaniappan,Dinakaran, Murugesan,Yogeeswari, Perumal,Sriram, Dharmarajan,China, Arnab,Nagaraja, Valakunja
experimental part, p. 345 - 358 (2009/05/09)
Various 1-(substituted)-1,4-dihydro-6-nitro-4-oxo-7-(sub-secondary amino)-quinoline-3-carboxylic acids were synthesized from 2,4-dichlorobenzoic acid by six step synthesis. The compounds were evaluated for antimycobacterial in vitro and in vivo against My
Process for the production of nitro derivatives of aromatic compounds
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, (2008/06/13)
Nitroderivates of aromatic compounds which are difficult to nitrate, can readily be obtained by nitration providing that the aromatic compound is treated with nitric acid or another nitrating agent in the presence of aliphatic or cycloaliphatic hydrocarbons monosubstituted or polysubstituted by halogen, the nitro group or an alkyl sulphonyl group, and the nitro derivative formed subsequently isolated.
