5-hydroxy-4-methyl-2-benzofuran-1(3H)-one

Base Information

• Chemical Name: 5-hydroxy-4-methyl-2-benzofuran-1(3H)-one
• CAS No.: 1194700-73-6
• Molecular Formula: C₉H₈O₃
• Molecular Weight: 164.161
• Mol file: 1194700-73-6.mol

Synonyms:5-hydroxy-4-methyl-2-benzofuran-1(3H)-one;5-hydroxy-4-methylisobenzofuran-1(3H)-one

Chemical Property of 5-hydroxy-4-methyl-2-benzofuran-1(3H)-one

Chemical Property:

• Boiling Point: 431.8±45.0 °C(Predicted)
• PKA: 8.42±0.20(Predicted)
• PSA: 46.53000
• Density: 1.359±0.06 g/cm3(Predicted)
• LogP: 1.37100
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

5-Hydroxy-4-methylisobenzofuran-1(3H)-one 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-hydroxy-4-methyl-2-benzofuran-1(3H)-one

There total 8 articles about 5-hydroxy-4-methyl-2-benzofuran-1(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

carbon monoxide (201230-82-2) + 6-bromo-3-hydroxy-2-methylbenzenemethanol (1255206-72-4) → 5-hydroxy-4-methyl-3H-isobenzofuran-1-one (1194700-73-6)

Guidance literature:

With 1,3-bis-(diphenylphosphino)propane; sodium acetate; palladium diacetate; In tetrahydrofuran; at 128 - 132 ℃; for 24h; under 4125.41 - 4875.49 Torr; Large scale;

DOI:10.1021/acs.oprd.0c00314

Reference yield:

6-bromo-3-hydroxy-2-methylbenzenemethanol (1255206-72-4) + copper(l) cyanide → 5-hydroxy-4-methyl-3H-isobenzofuran-1-one (1194700-73-6)

Guidance literature:

6-bromo-3-hydroxy-2-methylbenzenemethanol; copper(l) cyanide; In N,N-dimethyl-formamide; at 145 ℃; for 2h; Inert atmosphere;

With water; In N,N-dimethyl-formamide; at 95 ℃; for 20h; Inert atmosphere;

Reference yield:

6-bromo-3-hydroxy-2-methylbenzenemethanol (1255206-72-4) → 5-hydroxy-4-methyl-3H-isobenzofuran-1-one (1194700-73-6)

Guidance literature:

With copper(I) cyanide; In N,N-dimethyl-formamide; at 145 ℃; Inert atmosphere;

upstream raw materials:

6-bromo-3-hydroxy-2-methylbenzenemethanol

3-hydroxy 2-methylbenzoic acid

3-hydroxymethyl-2-methylphenol

copper(I) cyanide

Downstream raw materials:

trifluoromethanesulfonic acid 4-methyl-1-oxo-1,3-dihydro-isobenzofuran-5-yl ester

4-methyl-5-[2R-oxiran-2-yl]-2-benzofuran-1(3H)-one

1,3-dihydro-1-oxo-4-methyl-5-(2-bromoacetyl)isobenzofuran

5-bromo-4-methyl-2-benzofuran-1(3H)-one

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1194700-73-6 5-hydroxy-4-methyl-2-benzofuran-1(3H)-one

Send

Send

Metric Ton KG G Pound L ML

Send

Send