FMoc-α-Me-Pro-OH

Base Information

• Chemical Name: FMoc-α-Me-Pro-OH
• CAS No.: 167275-47-0
• Molecular Formula: C21H21NO4
• Molecular Weight: 351.4
• Mol file: 167275-47-0.mol

Synonyms:FMoc-α-Me-Pro-OH;Fmoc-alpha-Me-L-Pro-OH;N-Fmoc-α-methyl-L-proline;1-Fmoc-2-methyl-L-proline;(S)-1-(((9H-Fluoren-9-yl)methoxy)carbonyl)-2-methylpyrrolidine-2-carboxylic acid

Chemical Property of FMoc-α-Me-Pro-OH

Chemical Property:

• PSA: 66.84000
• LogP: 3.81250
• Storage Temp.: 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

Fmoc-alpha-Me-L-Pro-OH ^*data from reagent suppliers

Safty Information:

• Hazard Codes: F,T
• Statements: 14/15-24/25-34
• Safety Statements: 26-36/37/39-43-45

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of FMoc-α-Me-Pro-OH

There total 3 articles about FMoc-α-Me-Pro-OH which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

(fluorenylmethoxy)carbonyl chloride (28920-43-6) + 1.3-chlorobromopropane (109-70-6) → 2-methyl-pyrrolidine-1,2-dicarboxylic acid 1-(9H-fluoren-9-ylmethyl) ester (167275-47-0) + 5-chloro-2-[[(9H-fluoren-9-ylmethoxy)carbonyl]amino]-2-methylpentanoic acid

Guidance literature:

Multistep reaction;

DOI:10.1021/jo016236i

Reference yield:

(fluorenylmethoxy)carbonyl chloride (28920-43-6) + (S)-2-methylpyrrolidine-2-carboxylic acid (42856-71-3) → (S)-1-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)-2-methylpyrrolidine-2-carboxylic acid (1286768-33-9,167275-47-0)

Guidance literature:

With sodium carbonate; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; water; at 20 ℃; Alkaline conditions;

DOI:10.1074/jbc.M109.060939

Reference yield:

(fluorenylmethoxy)carbonyl chloride (28920-43-6) + 1.3-chlorobromopropane (109-70-6) → 2-methyl-pyrrolidine-1,2-dicarboxylic acid 1-(9H-fluoren-9-ylmethyl) ester (167275-47-0)

Guidance literature:

Multistep reaction.;

DOI:10.1021/jo016236i

upstream raw materials:

(fluorenylmethoxy)carbonyl chloride

(S)-2-methylpyrrolidine-2-carboxylic acid

1.3-chlorobromopropane

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