2-Hydroxy-4-methoxy-3,6-dimethylbenzaldehyde

Base Information

• Chemical Name: 2-Hydroxy-4-methoxy-3,6-dimethylbenzaldehyde
• CAS No.: 34883-15-3
• Molecular Formula: C10H12O3
• Molecular Weight: 180.203
• Mol file: 34883-15-3.mol

Synonyms:2-Hydroxy-4-methoxy-3,6-dimethylbenzaldehyde;Rhizonaldehyde

Chemical Property of 2-Hydroxy-4-methoxy-3,6-dimethylbenzaldehyde

Chemical Property:

• Melting Point: 136 °C
• Boiling Point: 296.2±35.0 °C(Predicted)
• PKA: 8.25±0.20(Predicted)
• PSA: 46.53000
• Density: 1.154±0.06 g/cm3(Predicted)
• LogP: 1.83010

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-Hydroxy-4-methoxy-3,6-dimethylbenzaldehyde

There total 17 articles about 2-Hydroxy-4-methoxy-3,6-dimethylbenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

2,4-Dimethoxy-3,6-dimethylbenzaldehyde (38629-39-9) → 4-methoxy-3,6-dimethyl-2-hydroxybenzaldehyde (34883-15-3)

Guidance literature:

With aluminum (III) chloride; In toluene; at 0 ℃; for 8h;

Reference yield:

ethyl everninate (6110-36-7) → 4-methoxy-3,6-dimethyl-2-hydroxybenzaldehyde (34883-15-3)

Guidance literature:

Multi-step reaction with 8 steps

1: TiCl₄

2: H₂, AcOH / Pd-C

3: K₂CO₃

4: KOH

5: K₂CO₃

6: LiAlH₄

7: MnO₂

8: BCl₃

With manganese(IV) oxide; potassium hydroxide; lithium aluminium tetrahydride; hydrogen; boron trichloride; titanium tetrachloride; potassium carbonate; acetic acid; palladium on activated charcoal;

Reference yield:

ethyl 2-hydroxy-3-formyl-4-methoxy-6-methylbenzoate (38629-37-7) → 4-methoxy-3,6-dimethyl-2-hydroxybenzaldehyde (34883-15-3)

Guidance literature:

Multi-step reaction with 7 steps

1: H₂, AcOH / Pd-C

2: K₂CO₃

3: KOH

4: K₂CO₃

5: LiAlH₄

6: MnO₂

7: BCl₃

With manganese(IV) oxide; potassium hydroxide; lithium aluminium tetrahydride; hydrogen; boron trichloride; potassium carbonate; acetic acid; palladium on activated charcoal;

upstream raw materials:

3-methoxy-2,5-dimethylphenol

Formanilid

2,4-dihydroxy-6-methylbenzaldehyde

methyl iodide

Downstream raw materials:

2-hydroxy-4-methoxy-3,6-dimethyl-benzaldehyde-oxime

3-methoxy-2,5,6-trimethylphenol

2-Benzyloxy-4-methoxy-3,6-dimethyl-benzaldehyde

2-Benzyloxy-4-methoxy-3,6-dimethylphenol