N,N-Dipropyl-3-nitrobenzeneacetaMide

Base Information

• Chemical Name: N,N-Dipropyl-3-nitrobenzeneacetaMide
• CAS No.: 97351-97-8
• Molecular Formula: C14H20N2O3
• Molecular Weight: 264.324
• Mol file: 97351-97-8.mol

Synonyms:N,N-Dipropyl-3-nitrobenzeneacetaMide;3-nitro-N,N-dipropylbenzeneacetamide

Chemical Property of N,N-Dipropyl-3-nitrobenzeneacetaMide

Chemical Property:

• PSA: 66.13000
• LogP: 3.30910
• Solubility.: Chloroform, Methanol

Purity/Quality:

99% ^*data from raw suppliers

N,N-Dipropyl-3-nitrobenzeneacetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Intermediate in the preparation of Ropinirole derivatives.

Technology Process of N,N-Dipropyl-3-nitrobenzeneacetaMide

There total 2 articles about N,N-Dipropyl-3-nitrobenzeneacetaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-nitro-benzeneacetic acid (1877-73-2) → N,N-di-n-propyl-2-(3-nitrophenyl)acetamide (97351-97-8)

Guidance literature:

Multi-step reaction with 2 steps

1: SOCl₂ / benzene / 3 h / Heating

2: benzene

With thionyl chloride; In benzene;

DOI:10.1021/jm00129a017

Reference yield:

(3-nitrophenyl)acetyl chloride (38411-41-5) + di-n-propylamine (142-84-7) → N,N-di-n-propyl-2-(3-nitrophenyl)acetamide (97351-97-8)

Guidance literature:

With triethylamine; In dichloromethane; Yield given; Heating;

DOI:10.1021/jm00148a028

Reference yield: 86.0%

N,N-di-n-propyl-2-(3-nitrophenyl)acetamide (97351-97-8) → N,N-di-n-propyl-2-(3-aminophenyl)acetamide (122520-07-4)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; for 2h; under 1551.4 Torr;

DOI:10.1021/jm00129a017

upstream raw materials:

(3-nitrophenyl)acetyl chloride

di-n-propylamine

3-nitro-benzeneacetic acid

Downstream raw materials:

3-nitro-N,N-dipropylbenzeneethanamine

N,N-di-n-propyl-2-(3-aminophenyl)acetamide

3'-<2-(N,N-di-n-propylamino)ethyl>aniline

N-<3-<2-(dipropylamino)ethyl>phenyl>acetamide