38411-41-5Relevant articles and documents
CEPHALOSPORIN CIPROFLOXACIN HYBRID COMPOUNDS
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Page/Page column 35; 39; 48, (2020/06/05)
A compound of formula (Ia) and related aspects.
COMPOUND, CURED PRODUCT, POLYMER, PHOTO-ALIGNMENT FILM, OPTICALLY ANISOTROPIC BODY AND LIQUID CRYSTAL DISPLAY ELEMENT
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Paragraph 0210, (2018/08/30)
A compound and a polymer which can each form a photo-alignment film having excellent ability of controlling alignment, a photo-alignment film obtained using the polymer and an optically anisotropic body and a liquid crystal display element each having the photo-alignment film are provided. A compound represented by the general formula (1). In the formula, P represents a polymerizable group, Z and Z1 represent divalent linking groups, A and A1 represent divalent cyclic groups, and X1 to X5 each independently represent a hydrogen atom, a fluorine atom, a chlorine atom, a hydroxy group, a nitro group, a cyano group or an alkyl group having 1 to 40 carbon atoms which may have a substituent, provided that X1, X2, X4 and X5 are not simultaneously hydrogen atoms.
Development of a photoswitchable antagonist of NMDA receptors
Hartrampf, Felix W.W.,Barber, David M.,Gottschling, Kevin,Leippe, Philipp,Hollmann, Michael,Trauner, Dirk
, p. 4905 - 4912 (2017/07/27)
N-methyl–Daspartate receptors (NMDARs) are vital for neurological processes such as learning, memory, and synaptic plasticity. As such, small molecules that modulate their function are of interest in the study of numerous neurological diseases. We have synthesized a small library of photoswitches that modulate NMDAR function. The most efficient photoswitch to date is based on a known ligand of the glycine binding site and shows significant subtype selectivity.
CYCLOPROPYL-FUSED-1,3-THIAZEPINES AS BACE1 AND/OR BACE2 INHIBITORS
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Paragraph 0254, (2013/03/26)
The present invention provides cyclopropyl-fused-1,3-thiazepines of formula I having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active comp
CYCLOPROPYL-FUSED-1,3-THIAZEPINES AS BACE 1 AND/OR BACE 2 INHIBITORS
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Page/Page column 45, (2013/03/26)
The present invention provides cyclopropyl-fused-1,3-thiazepines of formula (I) having BACE1 and/or BACE2 inhibitory activity, their manufacture, pharmaceutical compositions containing them and their use as therapeutically active substances. The active co
AMINO - PYRIMIDINE COMPOUNDS AS INHIBITORS OF TBK1 AND/OR IKK EPSILON
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Page/Page column 123; 124, (2011/05/05)
The invention relates to certain aminopyrimidine compounds which inhibit TBK1 and/or IKK epsilon and which may therefore find application in treating inflammation, cancer, septic shock and/or Primary open Angle Glaucoma (POAG).
POTASSIUM ION CHANNEL MODULATORS and USES THEREOF
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Page/Page column 48, (2010/04/03)
Compounds of formula (I) and pharmacologically acceptable salts and pro-drugs thereof wherein: Ar1 and Ar2 are aryl or heteroaryl; a is 0 to 5; R1 is alkyl, halogen, haloalkyl, alkoxy, haloalkoxy, alkoxycarbonyl, carboxyl, hydroxyl, amino, monoalkylamino, dialkylamino, nitro, acylamino, alkoxycarbonylamino, alkylsulphonyl, alkylsulphonylamino or cyano and, where a is greater than 1, each substituent R1 may be the same or different; b is 0 to 5; R2 is alkyl, halogen, haloalkyl, haloalkoxy, alkoxy, alkoxycarbonyl, carboxyl, hydroxyl, amino, monoalkylamino, dialkylamino, nitro, acylamino, alkoxycarbonylamino, alkylsulphonyl, alkylsulphonylamino or cyano and where b is greater than 1, each substituent R2 may be the same or different; V is selected from the group consisting of (CR3aR3b)pCON(R3b)X and (CR3aR3b)pN(R3b)CO(X), wherein said groups are in the 3- (meta) or 4- (para) position with respect to the substituent Z; W is selected from the group consisting of NR4a, O, S, S=O, SO2 and C(R4aR4b)2; X is hydrogen, alkyl, hydroxyalkyl, alkoxyalkyl, haloalkoxyalkyl, aryloxyalkyl, cycloalkyl, aryl, heteroaryl, polyalkylene glycol, aminoalkyl, monoalkylaminoalkyl, dialkylaminoalkyl, alkyl that is substituted with a groups of formula of formula NR8R9 wherein R8 and R9 together with the nitrogen atom to which they are attached form a saturated or partially unsaturated heterocyclic group, carboxyalkyl, alkoxycarbonylalkyl, haloalkoxycarbonylalkyl or aralkyloxycarbonylalkyl; Y and Z are the same or different and each is a substituent selected from the group consisting of (CR5aR5b)n1, C=O, SO2, C(=O)NR5a; C(=O)NR5aSO2 and C=O(R5aR5b)n2; R3a, R3b, R4a, R4b, R5a and R5b are the same or different and each is selected from the hydrogen, alkyl, cycloalkyl, aryl and heteroaryl; n1 and n2 are the same or different and each is 0 to 2; and p is 0 to 2; are potassium ion channel modulators, making them particularly useful in treating and preventing conditions such as pain, lower urinary tract disorders and the like.
FUSED RING HETEROARYL KINASE INHIBITORS
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Page/Page column 56, (2010/04/30)
Provided herein are fused ring heteroaryl compounds useful in a variety of methods, including reducing the activity of certain kinases and treating certain disease states.
Synthesis and activity evaluation of benzoylurea derivatives as potential antiproliferative agents
Song, Dan-Qing,Wang, Yue-Ming,Du, Na-Na,He, Wei-Ying,Chen, Ke-Liang,Wang, Gui-Fang,Yang, Peng,Wu, Lian-Zong,Zhang, Xue-Bo,Jiang, Jian-Dong
scheme or table, p. 755 - 758 (2009/09/25)
3-Haloacylamino benzoylureas (3-HBUs) consist of a new family of tubulin ligands that kill cancer cells through mitotic arrest. In exploring the structure-activity relationship (SAR), 17 analogues defined through variations of formylurea at the 1-position
Development of N-[11C]methylamino 4-hydroxy-2(1H)-quinolone derivatives as PET radioligands for the glycine-binding site of NMDA receptors
Fuchigami, Takeshi,Haradahira, Terushi,Fujimoto, Noriko,Nojiri, Yumiko,Mukai, Takahiro,Yamamoto, Fumihiko,Okauchi, Takashi,Maeda, Jun,Suzuki, Kazutoshi,Suhara, Tetsuya,Yamaguchi, Hiroshi,Ogawa, Mikako,Magata, Yasuhiro,Maeda, Minoru
experimental part, p. 5665 - 5675 (2009/12/09)
In this study, we synthesized and evaluated several amino 4-hydroxy-2(1H)-quinolone (4HQ) derivatives as new PET radioligand candidates for the glycine site of the NMDA receptors. Among these ligands, we discovered that 7-chloro-4-hydroxy-3-{3-(4-methylam