(alphaS)-alpha-Aminobenzenebutanoyl-L-leucyl-L-phenylalanine methyl ester mono(trifluoroacetate)

Base Information

Chemical Name:(alphaS)-alpha-Aminobenzenebutanoyl-L-leucyl-L-phenylalanine methyl ester mono(trifluoroacetate)
CAS No.:868539-99-5
Molecular Formula:C28H36F3N3O5
Molecular Weight:567.606
Hs Code.:
Mol file:868539-99-5.mol

Synonyms:(alphaS)-alpha-Aminobenzenebutanoyl-L-leucyl-L-phenylalanine methyl ester mono(trifluoroacetate);(S)-Methyl-2-((S)-2-((S)-2-aMino-4-phenylbutanaMido)-4-Methyl;(S)-Methyl 2-((S)-2-((S)-2-aMino-4-phenylbutanaMido)-4-MethylpentanaMido)-3-phenylpropanoate trifluoroacetic acid;(αS)-α-Aminobenzenebutanoyl-L-leucyl-L-phenylalanine Methyl Ester Mono(trifluoroacetate)

Suppliers and Price of (alphaS)-alpha-Aminobenzenebutanoyl-L-leucyl-L-phenylalanine methyl ester mono(trifluoroacetate)

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
(αS)-α-Aminobenzenebutanoyl-L-leucyl-L-phenylalanineMethylEsterMono(trifluoroacetate)
1g
$ 820.00

Crysdot
(S)-Methyl2-((S)-2-((S)-2-amino-4-phenylbutanamido)-4-methylpentanamido)-3-phenylpropanoate2,2,2-trifluoroacetate 97%
1g
$ 904.00

Total 43 raw suppliers

Chemical Property of (alphaS)-alpha-Aminobenzenebutanoyl-L-leucyl-L-phenylalanine methyl ester mono(trifluoroacetate)

Chemical Property:

PSA：147.82000
LogP:4.49330
Storage Temp.:Hygroscopic, -20°C Freezer, Under inert atmosphere
Solubility.:DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

97% ^*data from raw suppliers

(αS)-α-Aminobenzenebutanoyl-L-leucyl-L-phenylalanineMethylEsterMono(trifluoroacetate) ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Uses (αS)-α-Aminobenzenebutanoyl-L-leucyl-L-phenylalanine Methyl Ester Mono(trifluoroacetate) is an intermediate of Carfilzomib (C183460) which is a second-generation proteasome inhibitor that is used as a treatment in relapsed and refractory multiple myeloma.

Technology Process of (alphaS)-alpha-Aminobenzenebutanoyl-L-leucyl-L-phenylalanine methyl ester mono(trifluoroacetate)

There total 5 articles about (alphaS)-alpha-Aminobenzenebutanoyl-L-leucyl-L-phenylalanine methyl ester mono(trifluoroacetate) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 868539-96-2
(S)-methyl 2-((S)-2-tert.butoxycarbonyIamino-4-phenylbutanamido-4-methylpentanamido)-3-phenylpropanoate

: 76-05-1
trifluoroacetic acid

: 868539-99-5
C₂HF₃O₂*C₂₆H₃₅N₃O₄

Guidance literature:: In dichloromethane; at 20 ℃; for 1h; Product distribution / selectivity;

Reference yield:

: 2577-90-4
methyl (2S)-2-amino-3-phenylpropanoate

: 868539-99-5
C₂HF₃O₂*C₂₆H₃₅N₃O₄

Guidance literature:: Multi-step reaction with 4 steps

1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 0 - 20 °C

2: dichloromethane / 3 h / 0 - 20 °C

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 0 - 20 °C

4: dichloromethane / 3 h / 0 - 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1016/j.bmc.2019.07.044

Reference yield:

: 15136-32-0,87976-66-7,120342-25-8,5874-73-7
(N-(tert-butoxycarbonyl)-L-leucinyl)-L-phenylalanine methyl ester

: 868539-99-5
C₂HF₃O₂*C₂₆H₃₅N₃O₄

Guidance literature:: Multi-step reaction with 3 steps

1: dichloromethane / 3 h / 0 - 20 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; benzotriazol-1-ol; N-ethyl-N,N-diisopropylamine / dichloromethane / 12 h / 0 - 20 °C

3: dichloromethane / 3 h / 0 - 20 °C

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane;
DOI:10.1016/j.bmc.2019.07.044