tert-butyl 5-(1-acetylpiperidin-4-yl)-1-(4-(tert-butoxycarbonyl)phenylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Base Information

Chemical Name:tert-butyl 5-(1-acetylpiperidin-4-yl)-1-(4-(tert-butoxycarbonyl)phenylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate
CAS No.:1430563-96-4
Molecular Formula:C₃₃H₄₃N₃O₆
Molecular Weight:0
Hs Code.:
Mol file:1430563-96-4.mol

Synonyms:tert-butyl 5-(1-acetylpiperidin-4-yl)-1-(4-(tert-butoxycarbonyl)phenylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

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Chemical Property of tert-butyl 5-(1-acetylpiperidin-4-yl)-1-(4-(tert-butoxycarbonyl)phenylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Chemical Property:

Purity/Quality:: 98%min ^*data from raw suppliers

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Technology Process of tert-butyl 5-(1-acetylpiperidin-4-yl)-1-(4-(tert-butoxycarbonyl)phenylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

There total 10 articles about tert-butyl 5-(1-acetylpiperidin-4-yl)-1-(4-(tert-butoxycarbonyl)phenylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1430563-95-3
5-(1-acetylpiperidin-4-yl)-2-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid

: 18144-47-3
tert-butyl 4-aminobenzoate

: 1430563-96-4
tert-butyl 5-(1-acetylpiperidin-4-yl)-1-(4-(tert-butoxycarbonyl)phenylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Guidance literature:: With pyridine; trichlorophosphate; In dichloromethane; at 0 ℃; for 3h;

Reference yield:

: 1430563-92-0
5-bromo-2-(tert-butoxycarbonyl)-3,4-dihydroisoquinoline-1-carboxylic acid methyl ester

: 1430563-96-4
tert-butyl 5-(1-acetylpiperidin-4-yl)-1-(4-(tert-butoxycarbonyl)phenylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium chloride; bis-triphenylphosphine-palladium(II) chloride / toluene / 24 h / 100 °C / Inert atmosphere

2.1: hydrogen; platinum(IV) oxide / ethanol / 24 h / 2844.39 Torr

2.2: 24 h

3.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 24 h

4.1: lithium hydroxide; water / tetrahydrofuran / 3 h

5.1: trichlorophosphate; pyridine / dichloromethane / 3 h / 0 °C

With pyridine; platinum(IV) oxide; bis-triphenylphosphine-palladium(II) chloride; water; hydrogen; N-ethyl-N,N-diisopropylamine; lithium chloride; lithium hydroxide; trichlorophosphate; In tetrahydrofuran; ethanol; dichloromethane; toluene;

Reference yield:

: 1109230-24-1
methyl 2-(2-bromophenyl)ethylcarbamate

: 1430563-96-4
tert-butyl 5-(1-acetylpiperidin-4-yl)-1-(4-(tert-butoxycarbonyl)phenylcarbamoyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate

Guidance literature:: Multi-step reaction with 9 steps

1.1: acetic acid; sulfuric acid / 0 - 20 °C

2.1: sodium hydroxide / ethanol; 1,4-dioxane / 0.5 h / 150 °C / Microwave irradiation

3.1: sodium hydroxide / 1,4-dioxane / 2 h

4.1: thionyl chloride / 50 °C

5.1: lithium chloride; bis-triphenylphosphine-palladium(II) chloride / toluene / 24 h / 100 °C / Inert atmosphere

6.1: hydrogen; platinum(IV) oxide / ethanol / 24 h / 2844.39 Torr

6.2: 24 h

7.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 24 h

8.1: lithium hydroxide; water / tetrahydrofuran / 3 h

9.1: trichlorophosphate; pyridine / dichloromethane / 3 h / 0 °C

With pyridine; platinum(IV) oxide; bis-triphenylphosphine-palladium(II) chloride; thionyl chloride; sulfuric acid; water; hydrogen; acetic acid; N-ethyl-N,N-diisopropylamine; lithium chloride; sodium hydroxide; lithium hydroxide; trichlorophosphate; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; toluene;