1-Azabicyclo[2.2.1]heptane-3-carboxylic acid, Methyl ester, exo-(±)-

Base Information

• Chemical Name: 1-Azabicyclo[2.2.1]heptane-3-carboxylic acid, Methyl ester, exo-(±)-
• CAS No.: 115594-66-6
• Molecular Formula: C₈H₁₃NO₂
• Molecular Weight: 155.197
• Mol file: 115594-66-6.mol

Synonyms:1-Azabicyclo[2.2.1]heptane-3-carboxylic acid, Methyl ester, exo-(±)-

Chemical Property of 1-Azabicyclo[2.2.1]heptane-3-carboxylic acid, Methyl ester, exo-(±)-

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Azabicyclo[2.2.1]heptane-3-carboxylic acid, Methyl ester, exo-(±)-

There total 8 articles about 1-Azabicyclo[2.2.1]heptane-3-carboxylic acid, Methyl ester, exo-(±)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

methanol (67-56-1) + 3-(1,3-dithian-2-ylidene)-1-azabicylo<2.2.1>heptane (114704-09-5) → endo-3-carbomethoxy-1-azabicylo<2.2.1>heptane (115594-66-6,121564-88-3,122684-38-2,129595-00-2,133963-77-6,133963-79-8) + (+/-)-exo-methyl 1-azabicyclo<2.2.1>heptane-3-carboxylate (115594-66-6,121564-88-3,122684-38-2,129595-00-2,133963-77-6,133963-79-8)

Guidance literature:

With hydrogenchloride; at 55 ℃; for 4h;

DOI:10.1021/jm00172a003

Reference yield: 80.0%

methanol (67-56-1) + 3-(1,3-dithian-2-ylidene)-1-azabicylo<2.2.1>heptane (114704-09-5) → endo-3-carbomethoxy-1-azabicylo<2.2.1>heptane (115594-66-6,121564-88-3,122684-38-2,129595-00-2,133963-77-6,133963-79-8) + (+/-)-exo-methyl 1-azabicyclo<2.2.1>heptane-3-carboxylate (115594-66-6,121564-88-3,122684-38-2,129595-00-2,133963-77-6,133963-79-8)

Guidance literature:

With hydrogenchloride; at 55 ℃; for 4h;

DOI:10.1021/jm00172a003

Reference yield:

1-azabicyclo[2.2.1]heptan-3-one (21472-89-9) → endo-3-carbomethoxy-1-azabicylo<2.2.1>heptane (115594-66-6,121564-88-3,122684-38-2,129595-00-2,133963-77-6,133963-79-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 1.) n-butyllithium / 1.) hexane, THF, -35 deg C, 1.5 h, 2.) a) -45 deg C to 22 deg C, b) 22 deg C, 1 h

2: 7 percent / HCl (gas) / 4 h / 55 °C

With hydrogenchloride; n-butyllithium;

DOI:10.1021/jm00172a003

upstream raw materials:

methanol

3-(1,3-dithian-2-ylidene)-1-azabicylo<2.2.1>heptane

1-azabicyclo[2.2.1]heptan-3-one

methyl 1-(2-methoxy-2-oxoethyl)pyrrolidine-3-carboxylate