5-Thiazolecarboxylic acid, 2,3-dihydro-4-methyl-2-thioxo-

Base Information

• Chemical Name: 5-Thiazolecarboxylic acid, 2,3-dihydro-4-methyl-2-thioxo-
• CAS No.: 57658-34-1
• Molecular Formula: C5H5NO2S2
• Molecular Weight: 175.232
• Hs Code.: 2934100090
• Mol file: 57658-34-1.mol

Synonyms:5-Thiazolecarboxylic acid, 2,3-dihydro-4-methyl-2-thioxo-;2,3-Dihydro-4-methyl-2-thioxo-5-thiazolecarboxylic acid;2-mercapto-4-methyl-5-Thiazolecarboxylic acid

Chemical Property of 5-Thiazolecarboxylic acid, 2,3-dihydro-4-methyl-2-thioxo-

Chemical Property:

• Melting Point: 250℃
• PSA: 117.23000
• Density: 1.62
• LogP: 1.43840
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

4-Methyl-2-thioxo-2,3-dihydrothiazole-5-carboxylicacid 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Thiazolecarboxylic acid, 2,3-dihydro-4-methyl-2-thioxo-

There total 2 articles about 5-Thiazolecarboxylic acid, 2,3-dihydro-4-methyl-2-thioxo- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 4-methyl-2-thioxo-2,3-dihydro-1,3-thiazole-5-carboxylate (17309-13-6) → 4-methyl-2-thioxo-2,3-dihydro-thiazole-5-carboxylic acid (57658-34-1)

Guidance literature:

With potassium hydroxide; at 20 ℃;

Reference yield:

4-methyl-2-thioxo-2,3-dihydro-thiazole-5-carboxylic acid methyl ester (76816-22-3) → 4-methyl-2-thioxo-2,3-dihydro-thiazole-5-carboxylic acid (57658-34-1)

Guidance literature:

With sodium hydroxide;

DOI:10.1021/ja01097a029

Reference yield: 93.0%

2-mercapto-4-methylthiazole-5-carboxylic acid (57658-34-1) → 4-methylthiazole-2-thiol (5685-06-3)

Guidance literature:

With acetic acid; In N,N-dimethyl-formamide; at 105 - 110 ℃; for 8h; Green chemistry;

upstream raw materials:

4-methyl-2-thioxo-2,3-dihydro-thiazole-5-carboxylic acid methyl ester

ethyl 4-methyl-2-thioxo-2,3-dihydro-1,3-thiazole-5-carboxylate

Downstream raw materials:

2-(2,5-dihydroxy-phenylsulfanyl)-4-methyl-thiazole-5-carboxylic acid

4-methylthiazole-5-carboxylic acid

4-methylthiazole-2-thiol