tert-butyl 4-((tert-butyldiphenylsilyloxy)methyl)-3-aza-bicyclo[4.1.0]heptane-3-carboxylate

Base Information

Chemical Name:tert-butyl 4-((tert-butyldiphenylsilyloxy)methyl)-3-aza-bicyclo[4.1.0]heptane-3-carboxylate
CAS No.:1417743-34-0
Molecular Formula:C₂₈H₃₉NO₃Si
Molecular Weight:465.708
Hs Code.:

Synonyms:tert-butyl 4-((tert-butyldiphenylsilyloxy)methyl)-3-aza-bicyclo[4.1.0]heptane-3-carboxylate

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Chemical Property of tert-butyl 4-((tert-butyldiphenylsilyloxy)methyl)-3-aza-bicyclo[4.1.0]heptane-3-carboxylate

Chemical Property:

Purity/Quality:: 98%min ^*data from raw suppliers

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Technology Process of tert-butyl 4-((tert-butyldiphenylsilyloxy)methyl)-3-aza-bicyclo[4.1.0]heptane-3-carboxylate

There total 5 articles about tert-butyl 4-((tert-butyldiphenylsilyloxy)methyl)-3-aza-bicyclo[4.1.0]heptane-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1417743-33-9
4-(((tert-butyldiphenylsilyl)oxy)methyl)-3-azabicyclo[4.1.0]heptane

: 1417743-34-0
tert-butyl 4-(((tert-butyldiphenylsilyl)oxy)methyl)-3-azabicyclo[4.1.0]heptane-3-carboxylate

Guidance literature:: With triethylamine; at 20 ℃; for 1h;

Reference yield:

: 1417743-29-3
N-(1-((tert-butyldiphenylsilyl)oxy)pent-4-en-2-yl)-4-methylbenzenesulfonamide

: 1417743-34-0
tert-butyl 4-(((tert-butyldiphenylsilyl)oxy)methyl)-3-azabicyclo[4.1.0]heptane-3-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 4 h / 20 °C

2.1: Grubbs catalyst first generation / dichloromethane / 20 °C

3.1: diethylzinc; trifluoroacetic acid / hexane; dichloromethane / 0.33 h

3.2: 6 h / 20 °C

4.1: ammonium chloride; magnesium / methanol / 2 h / 23 °C / Inert atmosphere

5.1: triethylamine / dichloromethane / 1 h / 20 °C

With Grubbs catalyst first generation; diethylzinc; ammonium chloride; caesium carbonate; magnesium; triethylamine; trifluoroacetic acid; In methanol; hexane; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1417743-30-6
N-allyl-N-(1-((tert-butyldiphenylsilyl)oxy)pent-4-en-2-yl)-4-methylbenzenesulfonamide

: 1417743-34-0
tert-butyl 4-(((tert-butyldiphenylsilyl)oxy)methyl)-3-azabicyclo[4.1.0]heptane-3-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: Grubbs catalyst first generation / dichloromethane / 20 °C

2.1: diethylzinc; trifluoroacetic acid / hexane; dichloromethane / 0.33 h

2.2: 6 h / 20 °C

3.1: ammonium chloride; magnesium / methanol / 2 h / 23 °C / Inert atmosphere

4.1: triethylamine / dichloromethane / 1 h / 20 °C

With Grubbs catalyst first generation; diethylzinc; ammonium chloride; magnesium; triethylamine; trifluoroacetic acid; In methanol; hexane; dichloromethane;