CarbaMic acid, N-[2-[(2-aMino-4-quinolinyl)oxy]ethyl]-, 1,1-diMethylethyl ester

Base Information

• Chemical Name: CarbaMic acid, N-[2-[(2-aMino-4-quinolinyl)oxy]ethyl]-, 1,1-diMethylethyl ester
• CAS No.: 1085412-36-7
• Molecular Formula: C₁₆H₂₁N₃O₃
• Molecular Weight: 303.361
• Mol file: 1085412-36-7.mol

Synonyms:CarbaMic acid, N-[2-[(2-aMino-4-quinolinyl)oxy]ethyl]-, 1,1-diMethylethyl ester;tert-butyl 2-(2-aMinoquinolin-4-yloxy)ethylcarbaMate

Chemical Property of CarbaMic acid, N-[2-[(2-aMino-4-quinolinyl)oxy]ethyl]-, 1,1-diMethylethyl ester

Chemical Property:

• PSA: 86.47000
• LogP: 3.69260
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98.5% ^*data from raw suppliers

tert-Butyl(2-((2-aminoquinolin-4-yl)oxy)ethyl)carbamate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of CarbaMic acid, N-[2-[(2-aMino-4-quinolinyl)oxy]ethyl]-, 1,1-diMethylethyl ester

There total 3 articles about CarbaMic acid, N-[2-[(2-aMino-4-quinolinyl)oxy]ethyl]-, 1,1-diMethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

2-(N-tert-butoxycarbonylamino)ethanol (26690-80-2) + 2-amino-1,4-dihydroquinolin-4-one (343868-71-3) → 4-(2-tert-butoxycarbonylamino-ethoxy)-quinolin-2-yl amine (1085412-36-7)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃; for 72h;

DOI:10.1021/jacs.1c08860

Reference yield: 65.0%

2-amino-quinolin-4-ol (42712-64-1) + 2-(N-tert-butoxycarbonylamino)ethanol (26690-80-2) → 4-(2-tert-butoxycarbonylamino-ethoxy)-quinolin-2-yl amine (1085412-36-7)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃; for 72h; Inert atmosphere;

DOI:10.1039/c2ob25830g

Reference yield: 65.0%

2-aminoquinolin-4-one + 2-(N-tert-butoxycarbonylamino)ethanol (26690-80-2) → 4-(2-tert-butoxycarbonylamino-ethoxy)-quinolin-2-yl amine (1085412-36-7)

Guidance literature:

With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 0 - 20 ℃; for 72h; Inert atmosphere;

DOI:10.1002/anie.201206281

upstream raw materials:

2-(N-tert-butoxycarbonylamino)ethanol

2-amino-1,4-dihydroquinolin-4-one

2-amino-quinolin-4-ol

Downstream raw materials:

4-(2-aminoethoxy)-N2,N6-bis(4-(2-aminoethoxy)quinolin-2-yl)pyridine-2,6-dicarboxamide tris(trifluoroacetate)

C₄₀H₃₆N₁₀O₇

C₄₈H₅₂Cl₂N₁₂O₆

Refernces

• 1、 Chen, Shuo-Bin,Chen, Xiu-Cai,Dai, Jing,Huang, Zhi-Shu,Luo, Wen-Hua,Shao, Wen,Tan, Jia-Heng,Tang, Gui-Xue,Zeng, Shu-Tang. "Monitoring and Modulating mtDNA G-Quadruplex Dynamics Reveal Its Close Relationship to Cell Glycolysis". supporting information. p. 20779 - 20791. Retrieved 2021/12/14.
• 2、 Müller, Sebastian,Sanders, Deborah A.,Di Antonio, Marco,Matsis, Stephanos,Riou, Jean-Fran?ois,Rodriguez, Rapha?l,Balasubramanian, Shankar. "Pyridostatin analogues promote telomere dysfunction and long-term growth inhibition in human cancer cells". supporting information; experimental part. p. 6537 - 6546. Retrieved 2012/09/08.