1-[2-(2,4-Dichlorophenyl)-2-(thiophen-3-ylmethoxy)ethyl]imidazole

Base Information

Chemical Name:1-[2-(2,4-Dichlorophenyl)-2-(thiophen-3-ylmethoxy)ethyl]imidazole
CAS No.:119386-74-2
Molecular Formula:C16H14Cl2N2OS
Molecular Weight:353.272
Hs Code.:
ChEMBL ID:CHEMBL4747120
DSSTox Substance ID:DTXSID601169164
Nikkaji Number:J1.250.851D

Synonyms:CHEMBL4747120;119386-74-2;DTXSID601169164;BDBM50559359;1-[2-(2,4-Dichlorophenyl)-2-(3-thienylmethoxy)ethyl]-1H-imidazole

Suppliers and Price of 1-[2-(2,4-Dichlorophenyl)-2-(thiophen-3-ylmethoxy)ethyl]imidazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 1 raw suppliers

Chemical Property of 1-[2-(2,4-Dichlorophenyl)-2-(thiophen-3-ylmethoxy)ethyl]imidazole

Chemical Property:

XLogP3:4.4
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:6
Exact Mass:352.0203896
Heavy Atom Count:22
Complexity:350

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC(=C(C=C1Cl)Cl)C(CN2C=CN=C2)OCC3=CSC=C3

Technology Process of 1-[2-(2,4-Dichlorophenyl)-2-(thiophen-3-ylmethoxy)ethyl]imidazole

There total 5 articles about 1-[2-(2,4-Dichlorophenyl)-2-(thiophen-3-ylmethoxy)ethyl]imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 34846-44-1
3-Bromomethylthiophene

: 24155-42-8
1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol

: 119386-74-2
1-(2-(2,4-dichlorophenyl)-2-(thiophen-3-ylmethoxy)ethyl)-1H-imidazole

Guidance literature:: 1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethan-1-ol; With tetrabutylammomium bromide; sodium hydroxide; In toluene; at 85 ℃; for 0.5h;

3-Bromomethylthiophene; In toluene; for 3h; Heating;
DOI:10.1016/j.bmcl.2020.127756

Reference yield:

: 46503-52-0
1-(2,4-dichlorophenyl)-2-(imidazol-1-yl)ethanone

: 119386-74-2
1-(2-(2,4-dichlorophenyl)-2-(thiophen-3-ylmethoxy)ethyl)-1H-imidazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium tetrahydroborate / methanol / 3 h / 0 °C / Reflux

2.1: tetrabutylammomium bromide; sodium hydroxide / toluene / 0.5 h / 85 °C

2.2: 3 h / Heating

With sodium tetrahydroborate; tetrabutylammomium bromide; sodium hydroxide; In methanol; toluene;
DOI:10.1016/j.bmcl.2020.127756

Reference yield:

: 2631-72-3
2,4-dichlorophenacyl bromide

: 119386-74-2
1-(2-(2,4-dichlorophenyl)-2-(thiophen-3-ylmethoxy)ethyl)-1H-imidazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / tetrahydrofuran / 3 h / 20 °C

2.1: sodium tetrahydroborate / methanol / 3 h / 0 °C / Reflux

3.1: tetrabutylammomium bromide; sodium hydroxide / toluene / 0.5 h / 85 °C

3.2: 3 h / Heating

With sodium tetrahydroborate; tetrabutylammomium bromide; potassium carbonate; sodium hydroxide; In tetrahydrofuran; methanol; toluene;
DOI:10.1016/j.bmcl.2020.127756