Methyl N-Trifluoroacetyldaunosaminide

Base Information

• Chemical Name: Methyl N-Trifluoroacetyldaunosaminide
• CAS No.: 51996-41-9
• Molecular Formula: C₉H₁₄F₃NO₄
• Molecular Weight: 257.21
• Mol file: 51996-41-9.mol

Synonyms:Methyl N-Trifluoroacetyldaunosaminide;Methyl 2,3,6-Trideoxy-3-[(2,2,2-trifluoroacetyl)aMino]-L-lyxo-hexopyranoside

Chemical Property of Methyl N-Trifluoroacetyldaunosaminide

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Boiling Point: 352.928°C at 760 mmHg
• Flash Point: 167.245°C
• PSA: 67.79000
• Density: 1.339g/cm³
• LogP: 0.56660
• Solubility.: Methanol, Water

Purity/Quality:

97% ^*data from raw suppliers

Methyl N-trifluoroacetyldaunosaminide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Intermediate in the production of Daunorubicin.

Technology Process of Methyl N-Trifluoroacetyldaunosaminide

There total 3 articles about Methyl N-Trifluoroacetyldaunosaminide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + N-trifluoroacetyl-α-L-daunosamine (51996-45-3) → Methyl-N-trifluoracetyldaunosaminid (51996-41-9)

Guidance literature:

With hydrogenchloride; for 16h; Inert atmosphere;

DOI:10.1016/j.tet.2008.10.013

Reference yield:

methanol (67-56-1) + 2,3,6-Trideoxy-3-trifluoroacetamido-L-lixo-hexopyranose (51996-45-3,56354-08-6,64429-67-0,71952-66-4,122350-89-4) → Methyl-N-trifluoracetyldaunosaminid (51996-41-9)

Guidance literature:

With hydrogenchloride; for 16h; Inert atmosphere;

DOI:10.1016/j.tet.2008.10.013

Reference yield:

→ Methyl-N-trifluoracetyldaunosaminid (51996-41-9)

Guidance literature:

Daunosamin*HCl, 1.)Trifluoracetanhydrid, 2.)Methanol;

DOI:10.1016/S0008-6215(00)82108-4

upstream raw materials:

methanol

N-trifluoroacetyl-α-L-daunosamine

2,3,6-Trideoxy-3-trifluoroacetamido-L-lixo-hexopyranose

Refernces

• 1、 Friestad, Gregory K.,Jiang, Tao,Fioroni, Gina M.. "Stereocontrol in radical Mannich equivalents for aminosugar synthesis: haloacetal and 2-(phenylthio)vinyl tethered radical additions to α-hydroxyhydrazones". experimental part. p. 11549 - 11557. Retrieved 2009/04/06.