2-Pentenoic acid, 5-[4-(phenylmethoxy)phenyl]-, ethyl ester, (2E)-

Base Information

• Chemical Name: 2-Pentenoic acid, 5-[4-(phenylmethoxy)phenyl]-, ethyl ester, (2E)-
• CAS No.: 1187819-82-4
• Molecular Formula: C20H22O3
• Molecular Weight: 310.393
• Mol file: 1187819-82-4.mol

Synonyms:2-Pentenoic acid, 5-[4-(phenylmethoxy)phenyl]-, ethyl ester, (2E)-

Chemical Property of 2-Pentenoic acid, 5-[4-(phenylmethoxy)phenyl]-, ethyl ester, (2E)-

Chemical Property:

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Pentenoic acid, 5-[4-(phenylmethoxy)phenyl]-, ethyl ester, (2E)-

There total 5 articles about 2-Pentenoic acid, 5-[4-(phenylmethoxy)phenyl]-, ethyl ester, (2E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 81.0%

3-(4-(benzyloxy)phenyl)propanal (68486-77-1) + ethyl (triphenylphosphoranylidene)acetate (1099-45-2) → (E)-ethyl 5-(4-(benzyloxy)phenyl)pent-2-enoate (1187819-82-4)

Guidance literature:

In dichloromethane; at 20 ℃; for 8h; Inert atmosphere;

DOI:10.1016/j.tetasy.2009.05.036

Reference yield:

benzyl bromide (100-39-0) → (E)-ethyl 5-(4-(benzyloxy)phenyl)pent-2-enoate (1187819-82-4)

Guidance literature:

Multi-step reaction with 4 steps

1.1: potassium carbonate / acetone / 4 h / Reflux

2.1: 9-bora-bicyclo[3.3.1]nonane / tetrahydrofuran / 0 - 20 °C / Inert atmosphere

2.2: 0 - 60 °C / Inert atmosphere

3.1: pyridinium chlorochromate / dichloromethane / 0 - 20 °C / Inert atmosphere

4.1: dichloromethane / 4 h / 20 °C

With potassium carbonate; 9-bora-bicyclo[3.3.1]nonane; pyridinium chlorochromate; In tetrahydrofuran; dichloromethane; acetone; 4.1: |Wittig Olefination;

DOI:10.1016/j.tetlet.2018.04.084

Reference yield:

3-[4-(benzyloxy)phenyl]propan-1-ol (61440-45-7) → (E)-ethyl 5-(4-(benzyloxy)phenyl)pent-2-enoate (1187819-82-4)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridinium chlorochromate / dichloromethane / 0 - 20 °C / Inert atmosphere

2: dichloromethane / 4 h / 20 °C

With pyridinium chlorochromate; In dichloromethane; 2: |Wittig Olefination;

DOI:10.1016/j.tetlet.2018.04.084

upstream raw materials:

3-(4-(benzyloxy)phenyl)propanal

ethyl (triphenylphosphoranylidene)acetate

benzyl bromide

4-(prop-2-enyl)phenol

Downstream raw materials:

(E)-5-(4-(benzyloxy)phenyl)pent-2-en-1-ol