2-Chloro-4-phenylbenzoic acid

Base Information

• Chemical Name: 2-Chloro-4-phenylbenzoic acid
• CAS No.: 5728-40-5
• Molecular Formula: C13H9ClO2
• Molecular Weight: 232.666
• Hs Code.: 2916399090
• Mol file: 5728-40-5.mol

Synonyms:2-Chloro-4-phenylbenzoic acid

Chemical Property of 2-Chloro-4-phenylbenzoic acid

Chemical Property:

• PSA: 37.30000
• LogP: 3.70520
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

2-Chloro-4-phenylbenzoicacid ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Chloro-4-phenylbenzoic acid

There total 10 articles about 2-Chloro-4-phenylbenzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.9%

2-chloro-4-iodobenzoic acid (145343-76-6) + phenyltin trichloride (1124-19-2) → 3-chloro-[1,1'-biphenyl]-4-carboxylic acid (5728-40-5)

Guidance literature:

With potassium hydroxide; at 40 ℃; for 24h;

DOI:10.1039/c2cy20636f

Reference yield:

4-Bromo-2-chloro-benzoic Acid (59748-90-2) + phenylboronic acid (98-80-6) → 3-chloro-[1,1'-biphenyl]-4-carboxylic acid (5728-40-5)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,4-dioxane; water; at 110 ℃; for 5h; Inert atmosphere;

DOI:10.1016/j.ejmech.2019.05.047

Reference yield:

→ 3-chloro-[1,1'-biphenyl]-4-carboxylic acid (5728-40-5)

Guidance literature:

DOI:10.1021/ja01281a047

upstream raw materials:

carbon dioxide

4-bromo-3-chloro-1,1'-biphenyl

3-chloro-[1,1'-biphenyl]-4-carbonitrile

3-chlorobiphenyl-4-amine

Downstream raw materials:

3-diphenylamino-biphenyl-4-carboxylic acid

3,10-diphenyl-10H-acridin-9-one

Refernces

• 1、 Zhao, Shizhen,Zhao, Liyu,Zhang, Xiangqian,Wei, Peng,Wu, Mengya,Su, Xin,Sun, Bin,Zhao, Dongmei,Cheng, Maosheng. "Design, synthesis and evaluation of biphenyl imidazole analogues as potent antifungal agents". supporting information. p. 2448 - 2451. Retrieved 2019/07/30.
• 2、 Pacardo, Dennis B.,Knecht, Marc R.. "Exploring the mechanism of Stille C-C coupling via peptide-capped Pd nanoparticles results in low temperature reagent selectivity". . p. 745 - 753. Retrieved 2013/03/28.