NULL

Base Information

• Chemical Name: NULL
• CAS No.: 35960-95-3
• Molecular Formula: C9H9NO3S
• Molecular Weight: 211.23766
• Hs Code.: 2930909090
• Mol file: 35960-95-3.mol

Synonyms:Methyl 2-phenylthioaMidoacetate

Chemical Property of NULL

Chemical Property:

• PSA: 77.46000
• LogP: 1.53600
• Storage Temp.: 2-8°C

Purity/Quality:

95+% ^*data from raw suppliers

Methyl2-phenylthioamidoacetate 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of NULL

There total 6 articles about NULL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

thiobenzoic acid (98-91-9) + Methyl azidoacetate (1816-92-8) → methyl hippurate (1205-08-9) + methyl N-(thiobenzoyl)glycinate (35960-95-3)

Guidance literature:

With triphenylphosphine; In neat (no solvent); at 180 ℃; for 0.25h; chemoselective reaction; Microwave irradiation;

DOI:10.1080/00397911.2011.606043

Reference yield: 83.0%

Methyl azidoacetate (1816-92-8) + methyl dithiobenzoate (2168-78-7) → methyl N-(thiobenzoyl)glycinate (35960-95-3) + methyl N-[α-(methylsulfanyl)benzylidene]glycinate (38648-75-8)

Guidance literature:

at 110 - 150 ℃; for 10h;

Reference yield:

phenylmagnesium bromide → methyl N-(thiobenzoyl)glycinate (35960-95-3)

Guidance literature:

Multi-step reaction with 2 steps

1: diethyl ether / Behandeln des Reaktionsprodukts mit wss. Natrium-chloracetat

2: aqueous NaOH

With sodium hydroxide; diethyl ether;

DOI:10.1007/BF03019812

upstream raw materials:

methoxycarbonylmethylamine

Carboxymethyl dithiobenzoate

methyl dithiobenzoate

Methyl azidoacetate

Downstream raw materials:

methyl N-[α-(methylsulfanyl)benzylidene]glycinate

Refernces

• 1、 Nagarajan, Sangaraiah,Shanmugavelan, Poovan,Sathishkumar, Murugan,Priyadharshini, Namachivayam,Sudakar, Padmanaban,Ponnuswamy, Alagusundaram. "Chemoselectivity in coupling of azides with thioacids in solution-phase and solvent-free conditions". . p. 668 - 680. Retrieved 2013/01/15.