N-(5-oxo-5,6,7,8-tetrahydronaphthalen-2-yl)benzenesulfonaMide

Base Information

• Chemical Name: N-(5-oxo-5,6,7,8-tetrahydronaphthalen-2-yl)benzenesulfonaMide
• CAS No.: 1000300-06-0
• Molecular Formula: C16H15NO3S
• Molecular Weight: 301.366
• Mol file: 1000300-06-0.mol

Synonyms:N-(5-oxo-5,6,7,8-tetrahydronaphthalen-2-yl)benzenesulfonaMide

Chemical Property of N-(5-oxo-5,6,7,8-tetrahydronaphthalen-2-yl)benzenesulfonaMide

Chemical Property:

• PSA: 71.62000
• LogP: 4.16020

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(5-oxo-5,6,7,8-tetrahydronaphthalen-2-yl)benzenesulfonaMide

There total 1 articles about N-(5-oxo-5,6,7,8-tetrahydronaphthalen-2-yl)benzenesulfonaMide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

6-amino-1-tetralone (3470-53-9) + benzenesulfonyl chloride (98-09-9) → N-(5-oxo-5,6,7,8-tetrahydro-naphthalen-2-yl)-benzenesulfonamide (1000300-06-0)

Guidance literature:

With pyridine; at 23 ℃; for 24h;

Reference yield: 44.0%

N-(5-oxo-5,6,7,8-tetrahydro-naphthalen-2-yl)-benzenesulfonamide (1000300-06-0) + trimethylsilyl cyanide (7677-24-9) → N-(5-cyano-7,8-dihydro-naphthalen-2-yl)-bezenesulfonamide (1000300-07-1)

Guidance literature:

N-(5-oxo-5,6,7,8-tetrahydro-naphthalen-2-yl)-benzenesulfonamide; trimethylsilyl cyanide; With zinc(II) iodide; for 15h;

With toluene-4-sulfonic acid; In toluene; for 3h; Heating / reflux;

Reference yield:

N-(5-oxo-5,6,7,8-tetrahydro-naphthalen-2-yl)-benzenesulfonamide (1000300-06-0) → N-(5-aminomethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-benzenesulfonamide hydrochloride

Guidance literature:

Multi-step reaction with 3 steps

1.1: zinc(II) iodide / 15 h

1.2: 3 h / Heating / reflux

2.1: hydrogen; acetic acid / palladium 10% on activated carbon / ethanol / 15 h / 2844.39 Torr

3.1: borane-THF / tetrahydrofuran / 15 h / 0 - 20 °C

With borane-THF; hydrogen; acetic acid; zinc(II) iodide; palladium 10% on activated carbon; In tetrahydrofuran; ethanol;

upstream raw materials:

6-amino-1-tetralone

benzenesulfonyl chloride

Downstream raw materials:

N-(5-cyano-7,8-dihydro-naphthalen-2-yl)-bezenesulfonamide

N-(5-cyano-5,6,7,8-tetrahydro-naphthalen-2-yl)-benzenesulfonamide

Refernces