5,6-CARBOXYFLUORESCEIN DIPIVALATE

Base Information

• Chemical Name: 5,6-CARBOXYFLUORESCEIN DIPIVALATE
• CAS No.: 144676-12-0
• Molecular Formula: C31H28O9
• Molecular Weight: 544.558
• Mol file: 144676-12-0.mol

Synonyms:5-CARBOXYFLUORESCEIN-PIV;5-CARBOXYFLUORESCEIN DIPIVALATE;5,6-CARBOXYFLUORESCEIN-PIV;5,6-CARBOXYFLUORESCEIN DIPIVALATE

Chemical Property of 5,6-CARBOXYFLUORESCEIN DIPIVALATE

Chemical Property:

• PSA: 125.43000
• LogP: 5.85580

Purity/Quality:

98% ^*data from raw suppliers

2-Bromo-5-fluorothiophene 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5,6-CARBOXYFLUORESCEIN DIPIVALATE

There total 5 articles about 5,6-CARBOXYFLUORESCEIN DIPIVALATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2,2-dimethylpropanoic anhydride (1538-75-6) + 5-carboxyfluoroscein (76823-03-5) → 3',6'-bis(2,2-dimethyl-1-oxopropoxy)-3-oxo-spiro[isobenzofuran-1(3H),9'-[9H]xanthene]-5-carboxylic acid (144676-12-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; for 18h;

Reference yield:

2,2-dimethylpropanoic anhydride (1538-75-6) + recorcinol (108-46-3) + trimellitic Anhydride (552-30-7,145253-53-8) → 3',6'-bis(2,2-dimethyl-1-oxopropoxy)-3-oxo-spiro[isobenzofuran-1(3H),9'-[9H]xanthene]-5-carboxylic acid (144676-12-0) + 3',6'-bis(2,2-dimethyl-1-oxopropoxy)-3-oxo-spiro[isobenzofuran-1(3H),9'-[9H]xanthene]-6-carboxylic acid (192374-17-7)

Guidance literature:

recorcinol; trimellitic Anhydride; With methanesulfonic acid; at 80 ℃; for 24h;

2,2-dimethylpropanoic anhydride; In tetrahydrofuran; at 110 ℃; for 3h;

Reference yield:

trimellitic Anhydride (552-30-7,145253-53-8) → 3',6'-bis(2,2-dimethyl-1-oxopropoxy)-3-oxo-spiro[isobenzofuran-1(3H),9'-[9H]xanthene]-5-carboxylic acid (144676-12-0)

Guidance literature:

Multi-step reaction with 2 steps

1: methanesulfonic acid / 80 °C

2: potassium carbonate / N,N-dimethyl-formamide / 18 h

With methanesulfonic acid; potassium carbonate; In N,N-dimethyl-formamide;

upstream raw materials:

pivaloyl chloride

5-carboxyfluorescein

2,2-dimethylpropanoic anhydride

5-carboxyfluoroscein

Downstream raw materials:

5-carboxyfluorescein dipivalate