1-benzyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride

Base Information

Chemical Name:1-benzyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride
CAS No.:94163-98-1
Molecular Formula:C18H20ClN
Molecular Weight:285.817
Hs Code.:

Synonyms:1-benzyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride

Suppliers and Price of 1-benzyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 4 raw suppliers

Chemical Property of 1-benzyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride

Chemical Property:

Melting Point:203.0-203.5 °C
PSA：3.24000
LogP:4.71580

Purity/Quality:: 99%,98% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 1-benzyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride

There total 4 articles about 1-benzyl-4-phenyl-1,2,3,6-tetrahydropyridine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 38025-45-5
1-benzyl-4-phenyl-1,2,3,6-tetrahydro-pyridine

: 94163-98-1
1-benzyl-4-phenyl-1,2,5,6-tetrahydropirydine hydrochloride

Guidance literature:: With hydrogenchloride; In diethyl ether; ethyl acetate;
DOI:10.1016/j.bmcl.2012.01.122

Reference yield:

: 108-86-1,52753-63-6
bromobenzene

: 94163-98-1
1-benzyl-4-phenyl-1,2,5,6-tetrahydropirydine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: iodine; magnesium / tetrahydrofuran / Inert atmosphere; Reflux

1.2: 3 h / 20 °C / Inert atmosphere; Cooling with ice

2.1: methanesulfonic acid / toluene / 4 h / Reflux

3.1: hydrogenchloride / diethyl ether; ethyl acetate

With hydrogenchloride; methanesulfonic acid; iodine; magnesium; In tetrahydrofuran; diethyl ether; ethyl acetate; toluene; 1.1: Grignard reaction / 1.2: Grignard reaction;
DOI:10.1016/j.bmcl.2012.01.122

Reference yield:

: 3612-20-2
1-phenylmethyl-4-piperidone

: 94163-98-1
1-benzyl-4-phenyl-1,2,5,6-tetrahydropirydine hydrochloride

Guidance literature:: Multi-step reaction with 3 steps

1.1: iodine; magnesium / tetrahydrofuran / Inert atmosphere; Reflux

1.2: 3 h / 20 °C / Inert atmosphere; Cooling with ice

2.1: methanesulfonic acid / toluene / 4 h / Reflux

3.1: hydrogenchloride / diethyl ether; ethyl acetate

With hydrogenchloride; methanesulfonic acid; iodine; magnesium; In tetrahydrofuran; diethyl ether; ethyl acetate; toluene; 1.1: Grignard reaction / 1.2: Grignard reaction;
DOI:10.1016/j.bmcl.2012.01.122