2,5-dimethyl-1-[(4-methylphenyl)methyl]-1H-pyrrole

Base Information

• Chemical Name: 2,5-dimethyl-1-[(4-methylphenyl)methyl]-1H-pyrrole
• CAS No.: 937662-73-2
• Molecular Formula: C14H17N
• Molecular Weight: 199.296
• Mol file: 937662-73-2.mol

Synonyms:2,5-dimethyl-1-[(4-methylphenyl)methyl]-1H-pyrrole;1H-PYRROLE, 2,5-DIMETHYL-1-[(4-METHYLPHENYL)METHYL]-;UKRORGSYN-BB BBR-047985

Chemical Property of 2,5-dimethyl-1-[(4-methylphenyl)methyl]-1H-pyrrole

Chemical Property:

Purity/Quality:

2,5-DIMETHYL-1-[(4-METHYLPHENYL)METHYL]-1H-PYRROLE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,5-dimethyl-1-[(4-methylphenyl)methyl]-1H-pyrrole

There total 3 articles about 2,5-dimethyl-1-[(4-methylphenyl)methyl]-1H-pyrrole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

2,5-hexanedione (110-13-4) + para-methylbenzylamine (104-84-7) → 2,5-dimethyl-1-(4-methylbenzyl)-1H-pyrrole (937662-73-2)

Guidance literature:

In neat (no solvent); at 20 ℃; for 0.166667h; Green chemistry;

DOI:10.1039/c4gc01523a

Reference yield: 87.0%

hexane-2,5-diol (2935-44-6) + para-methylbenzylamine (104-84-7) → 2,5-dimethyl-1-(4-methylbenzyl)-1H-pyrrole (937662-73-2)

Guidance literature:

With C₁₉H₃₅Cl₂CoN₂P; potassium tert-butylate; sodium triethylborohydride; In tetrahydrofuran; toluene; at 150 ℃; for 24h; Inert atmosphere; Molecular sieve; Schlenk technique;

DOI:10.1002/anie.201607742

Reference yield:

hexane-2,5-diol (2935-44-6) + 4-Methylbenzyl alcohol (589-18-4) → 2,5-dimethyl-1-pyrroline (822-64-0) + 2,5-Dimethylpyrrole (625-84-3) + 2,5-dimethyl-1-(4-methylbenzyl)-1H-pyrrole (937662-73-2)

Guidance literature:

With carbonylchlorohydrido(4,5-bis((diisopropylphosphino)methyl)acridine)ruthenium(II); ammonia; In toluene; at 150 ℃; for 24h; under 5250.53 Torr; Inert atmosphere; Glovebox;

DOI:10.1021/jacs.8b08385

upstream raw materials:

2,5-hexanedione

para-methylbenzylamine

hexane-2,5-diol

4-Methylbenzyl alcohol

Refernces

• 1、 Marvi, Omid,Nahzomi, Hossein Taherpour. "Grinding solvent-free paal-knorr pyrrole synthesis on smectites as recyclable and green catalysts". . p. 139 - 147. Retrieved 2018/04/23.
• 2、 Saeedian Moghadam, Ebrahim,Saravani, Farhad,Ostad, Seyednasser,Tavajohi, Shohreh,Pirali Hamedani, Morteza,Amini, Mohsen. "Design, synthesis and cytotoxicity evaluation of indibulin analogs". . p. 211 - 217. Retrieved 2018/08/07.