N-(6-Methoxy-pyridin-3-yl)-2,2-dimethyl-propionamide

Base Information

Chemical Name:N-(6-Methoxy-pyridin-3-yl)-2,2-dimethyl-propionamide
CAS No.:227180-19-0
Molecular Formula:C11H16N2O2
Molecular Weight:208.26
Hs Code.:
Mol file:227180-19-0.mol

Synonyms:N-(6-Methoxy-pyridin-3-yl)-2,2-dimethyl-propionamide;N-(6-methoxy-3-pyridinyl)-2,2-dimethylPropanamide

Suppliers and Price of N-(6-Methoxy-pyridin-3-yl)-2,2-dimethyl-propionamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Crysdot
N-(6-Methoxypyridin-3-yl)pivalamide 95+%
5g
$ 1196.00

Crysdot
N-(6-Methoxypyridin-3-yl)pivalamide 95+%
1g
$ 397.00

Chemenu
N-(6-Methoxypyridin-3-yl)pivalamide 95%
1g
$ 375.00

Chemenu
N-(6-Methoxypyridin-3-yl)pivalamide 95%
5g
$ 1127.00

Chemcia Scientific
N-(6-Methoxy-pyridin-3-yl)-2,2-dimethyl-propionamide 95%
5 G
$ 675.00

Total 2 raw suppliers

Chemical Property of N-(6-Methoxy-pyridin-3-yl)-2,2-dimethyl-propionamide

Chemical Property:

Boiling Point:355.7±27.0 °C(Predicted)
PKA:13.60±0.70(Predicted)
PSA：51.22000
Density:1.100±0.06 g/cm3(Predicted)
LogP:2.14780

Purity/Quality:

99% ^*data from raw suppliers

N-(6-Methoxypyridin-3-yl)pivalamide 95+% ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of N-(6-Methoxy-pyridin-3-yl)-2,2-dimethyl-propionamide

There total 1 articles about N-(6-Methoxy-pyridin-3-yl)-2,2-dimethyl-propionamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 6628-77-9
6-methoxy-pyridin-3-ylamine

: 3282-30-2
pivaloyl chloride

: 227180-19-0
2,2-dimethyl-N-<5-(2-methoxypyridinyl)>propanamide

Guidance literature:: With triethylamine; In dichloromethane; for 0.5h; Cooling with ice;

Reference yield: 54.0%

: 227180-19-0
2,2-dimethyl-N-<5-(2-methoxypyridinyl)>propanamide

: 227180-20-3
2,2-dimethyl-N-<4-iodo-6-methoxy-3-pyridinyl>propanamide

Guidance literature:: With iodine; tert.-butyl lithium; In tetrahydrofuran; pentane; -78 deg C, 75 min; RT, 30 min;
DOI:10.3987/com-98-s(h)111

Reference yield:

: 227180-19-0
2,2-dimethyl-N-<5-(2-methoxypyridinyl)>propanamide

: 2-tert-butyl-6-methoxy-5-phenylthiopyrido[3,4-d]pyrimidin-4(3H)-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-BuLi; TMEDA / diethyl ether / 3 h / -10 °C

1.2: 61 percent / diethyl ether / 1 h / cooling

2.1: acetic anhydride / 2 h / Heating

3.1: 1.43 g / NH₃ / 24 h / 20 °C

4.1: 2,2,6,6-tetramethylpiperidine; n-BuLi / tetrahydrofuran; hexane / 1 h / 0 °C

4.2: 71 percent / tetrahydrofuran; hexane / 1 h / -78 °C

With 2,2,6,6-tetramethyl-piperidine; n-butyllithium; N,N,N,N,-tetramethylethylenediamine; ammonia; acetic anhydride; In tetrahydrofuran; diethyl ether; hexane;
DOI:10.1016/j.tet.2004.02.040