2-{4-[4-Amino-2-(trifluoromethyl)phenyl]-1-piperazinyl}-1-ethanol

Base Information

• Chemical Name: 2-{4-[4-Amino-2-(trifluoromethyl)phenyl]-1-piperazinyl}-1-ethanol
• CAS No.: 1183251-84-4
• Molecular Formula: C₁₃H₁₈F₃N₃O
• Molecular Weight: 289.301
• Hs Code.: 2933599090
• Mol file: 1183251-84-4.mol

Synonyms:2-{4-[4-Amino-2-(trifluoromethyl)phenyl]-1-piperazinyl}-1-ethanol

Chemical Property of 2-{4-[4-Amino-2-(trifluoromethyl)phenyl]-1-piperazinyl}-1-ethanol

Chemical Property:

• PSA: 52.73000
• LogP: 1.98600

Purity/Quality:

98%min ^*data from raw suppliers

2-{4-[4-Amino-2-(trifluoromethyl)phenyl]-1-piperazinyl}-1-ethanol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-{4-[4-Amino-2-(trifluoromethyl)phenyl]-1-piperazinyl}-1-ethanol

There total 4 articles about 2-{4-[4-Amino-2-(trifluoromethyl)phenyl]-1-piperazinyl}-1-ethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(4-(4-nitro-2-(trifluoromethyl)phenyl)piperazin-1-yl)ethan-1-ol → 2-(4-(4-amino-2-(trifluoromethyl)phenyl)piperazin-1-yl)ethan-1-ol (1183251-84-4)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 3h;

Reference yield:

1-(2-hydroxyethyl)piperazine (103-76-4) → 2-(4-(4-amino-2-(trifluoromethyl)phenyl)piperazin-1-yl)ethan-1-ol (1183251-84-4)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / dimethyl sulfoxide / 90 °C

2: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

With palladium 10% on activated carbon; hydrogen; potassium carbonate; In methanol; dimethyl sulfoxide;

DOI:10.1016/j.bmcl.2022.128552

Reference yield:

2-Fluoro-5-nitrobenzotrifluoride (400-74-8) → 2-(4-(4-amino-2-(trifluoromethyl)phenyl)piperazin-1-yl)ethan-1-ol (1183251-84-4)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / dimethyl sulfoxide / 90 °C

2: palladium 10% on activated carbon; hydrogen / methanol / 20 °C

With palladium 10% on activated carbon; hydrogen; potassium carbonate; In methanol; dimethyl sulfoxide;

DOI:10.1016/j.bmcl.2022.128552

upstream raw materials:

1-(2-hydroxyethyl)piperazine

2-Fluoro-5-nitrobenzotrifluoride

Refernces

• 1、 -. "TGF-betaR1 inhibitor and application thereof". Paragraph 0738; 0743-0745. . Retrieved 2020/06/09.